Jimmy Moore: One thing we’ve not talked about, I alluded to a little bit earlier, is LDL particle size. When people hear LDL, they think “Oh that’s one number.” Uh-uh, it’s actually 2 major numbers, it’s a lot more than 2. It’s about 6 or 8 sub-fractions of LDL sizes. Primarily it’s pattern A and pattern B. Pattern A being the large fluffy kind. Pattern B being the small dense kind.
[13:30] – Why Dave had 63 blood tests in 18 months (68 up to this point)? The importance of multiple blood draws in interpreting lab results due to the 3-day window for LDL and HDL cholesterol. The same is true for particle counts (LDL-P), which are also on a 3-day window but with a 2-day gap. How the individual’s diet during that period affects the cholesterol levels significantly.
The keto diet works for such a high percentage of people because it targets several key, underlying causes of weight gain — including hormonal imbalances, especially insulin resistance coupled with high blood sugar levels, and the cycle of restricting and “binging” on empty calories due to hunger that so many dieters struggle with. In fact, these are some of the direct benefits of the keto diet.

While I would like to offer a magic bullet for all cancers, a ketogenic diet is not that. The diet does not “cure” cancer. It should not be used to replace traditional treatment. But the diet has shown promise for some cancers especially GBM. So why would a diet help? On a simplistic level, cancer “eats” glucose and needs 20 times more glucose compared to normal cells. Cancer cells cannot make the transition to using ketones, especially in the brain, making them more vulnerable to chemo and radiation.
When a person first starts onto a low-carbohydrate ketogenic diet, it takes the body several days to a few weeks to shift from relying on glucose to instead rely on fat. During this transition, people may experience what is sometimes referred to as the “keto-flu”—muscle cramps, headaches, fatigue, dizziness, nausea, and sugar and carbohydrate cravings.49 There may also be increased urination which can result in a loss of minerals, such as sodium and potassium. To counter these effects one should strive to get more minerals and in particular, more sodium and potassium, drink plenty of water, get some exercise and ensure adequate caloric intake. Once the body becomes keto-adapted, these symptoms largely resolve, and many people report increased energy, decreased cravings and weight loss.
Contemporary researchers like Dr. Thomas Seyfried and Dominic D’Agostino have argued that this dysregulated cellular energy production, or cellular metabolism, is actually what induces malignancy and that by extension, if we limit the fuels available for this process of fermentation, and the fuels are glucose, which is derived from carbohydrate in the diet, and glutamine, which is derived from protein in the diet, then we can actually starve cancer cells and either improve the results of conventional treatment or perhaps even address some cancers independently without conventional treatment.
May this letter find you and your loved ones happy and healthy for without you I would not be in such an improved state of physical health? It is not often I get to put pencil to paper for not only could I not concentrate due to opiate pharmaceuticals (couldn't express oneself due to lack of cognitive thinking) but the pain, inability to get comfortable due to lymphodemia and anxiety from stress (from lack of cash flow for food, bills, medicines plus the high expense of bandages & ointments) have prevented me from making contact but ....still after this prolonged period of time, I feel it necessary to write personally to mention just how dramatically you changed the world my two children and I live in. My sister Casey Lee Smith, arrived 6 months ago from the USA to run my household and it is through "Phoenix Tears" website she was able to make contact with you and learn all about the many wondrous benefits of medicinal Cannabis oil. When the treatment arrived, I was overwhelmed for I am a single Mother and your generosity brought tears to my eyes (even now it is hard to fight tears as I write) It has been rough to say the least. Feeling helpless, overly tired and frustrated by the lack of qualified physicians in my local town. I became depressed. My ex-husband felt he should prepare the kids for my untimely death. The location of my cancer spread throughout my left quadrant into my lymph and into the brain. I became bed ridden and lost hope. I will lose my house shortly but now i know it won't be my life. So, "THANK YOU" for the gracious gift and know you are loved! Sending love to you forever and always.

The ketogenic diet has been shown in many studies to be particularly helpful for some epilepsy conditions. These include infantile spasms, Rett syndrome, tuberous sclerosis complex, Dravet syndrome, Doose syndrome, and GLUT-1 deficiency. Using a formula-only ketogenic diet for infants and gastrostomy-tube fed children may lead to better compliance and possibly even improved efficacy.
People claiming huge benefits of these supplements – despite the lack of solid scientific support – may sometimes have a financial reason to believe in the supplements. Some of these products are sold under a multi-level marketing arrangement, where sales people are paid based on commission. For example, the company Prüvit sells drinkable ketones, called KETO//OS with a multi-level marketing structure.
A more recent clinical trial comparing a ketogenic diet (33.5% protein, 56% fat, 9.6% carbohydrate) to a low-fat diet (22% protein, 25% fat,55.7% carbohydrate) among 55 obese adults, showed that the ketogenic diet resulted in improved cholesterol levels compared to the low-fat diet. More specifically, the group following the ketogenic diet reported higher increases in HDL cholesterol and higher decreases in triglyceride levels compared to the control group (15).

The diet may not work for everyone but is suitable for many different seizure types and epilepsy syndromes, including myoclonic astatic epilepsy, Dravet syndrome, infantile spasms (West syndrome), and those with tuberous sclerosis. If you or your child has feeding problems, or has a condition where a high fat diet would cause problems, the diet may not be suitable.
Insulin Resistance, Metabolic Syndrome and Pre Diabetes: these conditions are directly related to the effects of chronically high blood sugar and insulin resulting in insulin resistance (IR).  In addition, related conditions such as fatty liver disease and PCOS are also caused by IR.  Low carb, high fat diets have been used in studies to treat and reverse all of these IR conditions.
Your child will begin the ketogenic diet within 24 hours of being admitted to the hospital. The diet contains a fixed amount of calories, carbohydrate, fat, and protein. Each meal has to be measured exactly and all the ingredients weighed in this diet. For young infants, pre-made, ready-to-use ketogenic formulas are available for use. Your child may also need supplements such as vitamins and extra calcium.

Within 7 days of initiating the ketogenic diet, blood glucose levels declined to low-normal levels and blood ketones were elevated twenty to thirty fold. Results of PET scans indicated a 21.8% average decrease in glucose uptake at the tumor site in both subjects. One patient exhibited significant clinical improvements in mood and new skill development during the study. She continued the ketogenic diet for an additional twelve months, remaining free of disease progression.
The ketogenic diet may also worsen some mitochondrial diseases, pyruvate carboxylase deficiency, or organic acidurias. In general a metabolic screen, including urine amino and organic acids, serum amino acids, lactate, pyruvate, and carnitine profile, should be performed before starting the ketogenic diet to make sure children do not have a contraindication to using it.
Weight Loss – Part of the resurgence in interest in the ketogenic diet is due to the work of Dr. Atkins and his low-carb diet for weight loss. There is strong evidence to support the use of a ketogenic diet as a weight loss therapy.18 19 People following a low-carb diet tend to lose more weight in the first 3-6 months than those following a more traditional diet.20 Part of the benefit likely comes from the fact that ketogenic diets tend to suppress appetite and lead to a natural decrease in calorie intake.21 But even in studies where participants on a low carb diet ate the same number of calories per day as those on a lowfat diet, significant differences in weight loss were observed.22 This is likely due to the fact that ketosis relies on fat from the diet and body fat to produce ketones for energy.
In talking with my patients, a major part of epilepsy they struggle with most is the lack of control. They worry about going out in public and suddenly having a seizure — there’s just no predictability to it whatsoever, and I think that causes major anxiety. A diet is something in their environment they can control. They can be in control of their treatment and seizures, and I think that empowers them.
There are now a number of different diets that can be used for epilepsy: the Classic Ketogenic Diet, the Modified Atkins Diet, the Medium Chain Triglyceride Diet and the Low Glycemic Index Treatment Diet. The choice is made after the initial consultation, and depends on the epilepsy diagnosis, the child’s age and feeding habits, and family needs and preferences. 

Sharon M. Nickols-Richardson, PhD, RD, , Mary Dean Coleman, PhD, RD, Joanne J. Volpe, Kathy W. Hosig, PhD, MPH, RD, “Perceived Hunger Is Lower and Weight Loss Is Greater in Overweight Premenopausal Women Consuming a Low-Carbohydrate/High-Protein vs High-Carbohydrate/Low-Fat Diet,” The Journal of Pediatrics: Vol 105, Issue 9: 1433–1437; September 2005. http://www.sciencedirect.com/science/article/pii/S000282230501151X.
The ketogenic diet now has nearly 100 years of history supporting its use. Most major medical textbooks and reviews no longer question its efficacy. About 50% of the children appear to have had an excellent response to the diet as defined by marked reduction (at least a 50% reduction) in seizure activity. About 15% of children become seizure-free after initiation of the ketogenic diet, usually within 3-6 months, and typically stop the diet after 2 years. Of those children who become seizure-free, a minority (15-20%) have recurrence after the diet is stopped. Risk factors that increase the likelihood of recurrence of seizures are:
Mitochondria generate reactive oxygen species (ROS) during their metabolic activities. In normal cells, the production of ROS and their elimination by antioxidants are kept in balance.10 Intriguingly, a higher incidence of errors, or mutations, in mitochondrial DNA have been observed in many human cancers, likely as a result of uncontrolled ROS production and oxidative stress.11
I’m not going to shell out 20k to know my LDL-P. I’d rather assume that I’m part of the 30% who reacts to saturated fat with elevated LDL-P. Should I be worried, considering all my other markers point to the right direction? Expert after expert say that we don’t know what these mixed signals mean until there is a study of people doing low-carb high-fat diets, correlating their lipid profiles with incidence of cardiovascular disease.
Like any trendy diet worth its balanced portion of salt, the keto diet is said to hold transformative powers. Proponents say it can help people lose weight, improve mood and experience fewer epileptic seizures. For the most part, the science seems to back these claims up — though, to be sure, it's not completely understood how exactly the keto diet affects mood (particularly depression), despite anecdotal evidence the diet might lead to clearer thinking and fewer symptoms of depression.
The most common side effect encountered is constipation. Many of the children who begin the diet are already prone to this problem because of limited mobility, hypotonia, or spasticity. Constipation can be treated with regular doses of polyethylene glycol, fiber, increased fluids, salt, mineral oil, intermittent pediatric-dose enemas, or magnesium hydroxide . Other more common side effects include hunger, acidosis (during illness), and hypoglycemia (just during the start of the diet). Many children as well can have gastroesophageal reflux, which can be managed with medications. The high fat content decreases gastric emptying, which promotes gastroesophageal reflux.

Jimmy Moore: You as the patient are actually the one in charge. This is one of the themes of my books Leanne, is I want to empower patients to take back control of their own health again. People see doctors, “Oh well they have all the answers about health.” No they don’t. They’ve been given, if there lucky, a week or two worth of nutritional health information in their medical training. Everything else is physiological and pharmacological. They’ve been trained to drug you up.
Keto is not hard to follow at all. See, this is why I took my diet and nutrition into my own hands. I have PCOS and the ketogenic diet has worked wonders for me. I’m finally pregnant at the age of 32 and after 11 years of marriage because the ketogenic diet made me lose over 100 lbs and brought my insulin resistance under control. I feel better than I’ve ever felt. Sometimes doctors don’t seem to know as much as they should, or as much as they assume they do, and that’s pretty disturbing. Just like they’re still using the old school and very inaccurate BMI charts that are just pure bs. I’ll just take care of myself outside of certain situations involving illness or injury. I’m doing great on my own.
Just this week as I write this, one of my newer patients, a wonderful, creative inventor and computer whiz from the Washington, DC area, came into my office for his regularly scheduled six month re-evaluation appointment. When he started with me in January 2010, three and a half years ago, he had been diagnosed with stage IV metastatic squamous cell carcinoma of the lung, with multiple tumors in both lungs and with evidence of metastases in his ribs. His local doctors in DC had explained he had terminal disease, for which chemotherapy would be useless.

Energy Deprivation. By its nature, the ketogenic diet is very low in carbohydrates (typically 20 to 50 grams/day) and naturally restricts calorie consumption. This restricts the amount of fuel that cancer cells receive, even for the cancer cells that are able to thrive off of multiple substrates. Furthermore, almost all cancer cells seem to lack the ability to use the ketones produced when carbs consumption is restricted. Thus, cancer patients who are keto-adapted will probably be the most effective at starving cancer cells.

A number of patients previously refractory to multiple anticonvulsant medications become seizure-free or maintain a significant reduction in seizure frequency even after the ketogenic diet has been discontinued, suggesting the diet may have disease-modifying effects in some people with epilepsy [19,20•, Class III]. No clinical factors have been identified that predict which patients will benefit most in this regard.
Finally a publication that explains how to fight cancer with a Ketogenic Diet. Easy to understand and follow. Great for helping those trying to follow this diet for someone who is battling, in our case Brain cancer. Thank you Ellen for all your hard work and dedication to keep this updated in a hope that we, as the readers and caretakers, can extend an awesome quality of life for those battling Glioblastoma Multiforme grade 4.
This describes me, too. I am not a doctor, but after months and years of research, have decided to follow the ketogenic lifestyle and the naturopathic cancer treatments prescribed by my physician. It took a few months to find a doctor who embraced this, but he is worth it. Keto had my diabetes under control long before we realized that cancer was trying to get me as well. I take no chemical drugs for anything. Diet, exercise, and a few supplements take care of my health needs. You don’t know me, but three years ago, I needed a walker and a wheelchair. Today at 60, I walk under my own power and ride a bicycle as much as possible. Go as natural as you can, it helps. Stay away from “products” and just eat fresh, whole, natural food. (The article shows these.)
One approach to this question has been to examine the variations in the size of the LDL particles in the blood. With a well-formulated ketogenic diet, we see a shift away from the small dangerous LDL even when the total LDL goes up, so most of this increase is in the ‘good’ or ‘buoyant’ LDL fraction (Hallberg, 2018). Another factor to be taken into account is that during rapid weight loss, cholesterol that you had stored in your adipose tissue (ie, body fat) is mobilized as the fat cells shrink (Phinney 1990). This will artificially raise serum LDL as long as the weight loss continues, but it then comes back down once weight loss stops. To avoid being misled by this, the best strategy is to hold off checking blood lipids until a couple of months after weight loss ceases.
A randomised, parallel-group trial among 307 obese participants demonstrated that a low-carbohydrate, high-fat diet resulted in lower levels of diastolic blood pressure, triglyceride, and LDL cholesterol levels in the first 6 months compared to the low-fat diet group. Moreover, the HDL cholesterol increased by 23% after 2 years in the low-carbohydrate, high-fat diet group (14).
Research suggests that cancer cells with low levels of particular enzymes (the ketolytic enzymes 3-hydroxybutyrate dehydrogenase and succinyl CoA 3-oxoacid CoA transferase) are more susceptible to the anticancer effects of a ketogenic diet. Screening a patient’s cancer cells for these enzymes may represent a valuable strategy for determining whether a ketogenic diet may be of use. (39)
Sharon M. Nickols-Richardson, PhD, RD, , Mary Dean Coleman, PhD, RD, Joanne J. Volpe, Kathy W. Hosig, PhD, MPH, RD, “Perceived Hunger Is Lower and Weight Loss Is Greater in Overweight Premenopausal Women Consuming a Low-Carbohydrate/High-Protein vs High-Carbohydrate/Low-Fat Diet,” The Journal of Pediatrics: Vol 105, Issue 9: 1433–1437; September 2005. http://www.sciencedirect.com/science/article/pii/S000282230501151X.
It’s a habit to enjoy a brie cheese for desert instead of a piece of chocolate cake but each are favored deserts in France. I’m personally more satisfied after a 350 calorie sized wedge of brie than the same number of calories of cake.. which will give me sugar crash and .. really I’d like two slices of cake(I’ve got a sweet tooth that once I get going it wants to keep being fed)

Take your stress hormone cortisol: It stays highest in the morning and gradually tapers throughout the day. Measuring cortisol in the morning might yield an entirely different result from testing in the evening. Researchers speculate ketogenic diets might raise this stress hormone, but many other factors also come into play here that may have nothing to do with your diet.
I think it was still hard for him to accept that many cancer patients, and many humans without cancer, did best on a plant-based, high carb diet, so foreign to his way of thinking. Though he had heard me expound on the Kelley approach many times over the years, it was to him implausible that humans as a species had adopted to a variety of diets, some high fat, some high carb, some more balanced, and that in medical practice, we as physicians had to be aware that different patients might require completely different diets for optimal health.
Now that we have a superficial understanding of the total-to-HDL cholesterol ratio, let’s look at the results of the meta-analysis. The two findings that the researcher’s highlight most are the effects that lauric acid (found in high quantities in coconut oil) and stearic acid (found in high quantities in animal fats) have on the total-to-HDL cholesterol ratio. Both of these fatty acids improved the total-to-HDL cholesterol ratio more favorably than carbohydrates [25]. (A similar pattern emerges for blood sugar and triglyceride levels when we replace carbs with fat as well.)
Make things yourself. While it’s extremely convenient to buy most things pre-made or pre-cooked, it always adds to the price per pound on items. Try prepping veggies ahead of time instead of buying pre-cut ones. Try making your stew meat from a chuck roast. Or, simply try to make your mayo and salad dressings at home. The simplest of things can work to cut down on your overall grocery shopping.
Similar trends in adverse events have been noted in children. One key concern is the high risk of osteoporosis, which reaches as high as 20% in KD cases. Along with osteoporosis come growth issues. “Children on the classic KD do often grow slightly slower than children not on the diet. When the diet stops, there is ‘catch-up’ growth, usually to normal,” said Kossoff.
The mainstay of treatment for epilepsy is pharmaceutical intervention. As I recently noted, more and more we are seeing surgical procedures being performed for those individuals who have not had a significant improvement with drugs. I indicated that at least some individuals are gluten sensitive and may benefit from a gluten-free diet which potentially could keep them from undergoing potentially life-threatening surgery as a treatment for their epilepsy.
In children who can be successfully withdrawn from anti-convulsant therapy and are seizure-free for 2 years on the ketogenic diet (about 10 percent of treated children), an EEG is repeated and the ketogenic diet is slowly withdrawn. However, the diet is often stopped earlier if not successful. Similarly, after 2 years in children with continued seizures, most ketogenic diet centers will at least try to have the children come off the diet and see if it is no longer necessary for control.
A popular alternative that helps many is called the Modified Atkins Diet. This diet is far less restrictive, as calories, fluids, and protein are not measured. The diet begins with 10 grams of carbohydrate per day for the first month, and then slowly moving to 15 or 20 grams. It is similar to a very strict induction phase of Atkins. There has been at least one study, though, where some achieved better seizure control when they switched from the Atkins diet to the KDE.

Thanks for this article. I just started a Keto diet so found it appropriate to my current lifestyle. Though I don’t believe your bottom line is strong enough since you simply stating that the diet is “hard to follow” and food is “notoriously unhealthy” without evidence going deeper into why those “notoriously unhealthy” foods are worse than keeping carbohydrate-heavy food that are addictive and give the body a quick sugar high for energy. I believe “hard to follow” is your opinion only, since acceptable Keto foods are found at all restaurants easily and also all grocery stores. All the foods you mention: “rich in very colorful fruits and vegetables, lean meats, fish, whole grains, nuts, seeds, olive oil, and lots of water” are all Keto-friendly. Many people have been on a Keto-diet for years. A healthy lifestyle is a healthy mindset change and making right choices – it’s not going to be easy.
A small Feb. 20, 2017, study looked at the impact of a six-week ketogenic diet on physical fitness and body composition in 42 healthy adults. The study, published in the journal Nutrition & Metabolism, found a mildly negative impact on physical performance in terms of endurance capacity, peak power and faster exhaustion. Overall, researchers concluded, “Our findings lead us to assume that a [ketogenic diet] does not impact physical fitness in a clinically relevant manner that would impair activities of daily living and aerobic training.” The “significant” weight loss of about 4.4 pounds, on average, did not affect muscle mass or function.

According to a 2015 review of the literature on the ketogenic diet for human glioma patients (32 case studies), “Prolonged remissions ranging from more than 5 years to 4 months were reported in the case reports. Only one of these patients was treated using KD as monotherapy. The best responses reported in the more recent patient series were stable disease for approximately 6 weeks.”
Dave Feldman recently demonstrated that increasing net carb intake from 30 grams to 95 grams per day – (going from 4% of total calories to 13% of total calories) led to a significant drop in his LDL cholesterol level. Obviously, this level of carb intake isn't ketogenic; however, it is still moderately low carb. On the other hand, this will likely increase your blood sugar and insulin levels to some extent.
Cyclical ketosis means you’re sometimes in ketosis and sometimes aren’t. A few days each week—the night before workout days to build glycogen stores in your muscles—try increasing your intake of berries, higher complex carb veggies (like sweet potatoes), and non-gluten grains. It might knock you out of ketosis temporarily, but it also provides a wealth of nutrients to keep you lean, healthy, and happy. This is also called flexible ketosis, which creates metabolic flexibility—the holy grail of metabolism management. I’ve also talked about cycling ketosis with intermittent fasting, which provides a win-win strategy to reach your health goals.

3. The Low Glycemic Index Treatment (LGIT, uses a liberalized but still low carbohydrate intake, with carbohydrates supplied only in the form of low-glycemic index foods (glycemic index of less than 50 relative to glucose). Of the 20 patients initially studied on this diet in 2005, 10 experienced a greater than 90% reduction in seizure frequency. The LGIT can be started as an outpatient without a fasting period. An updated study in 2009 included 76 children, of which 50% of those remaining on the diet at 3 months had a >50% seizure reduction.
Hi Barb, That can definitely be it. Losing when you are close to goal can be more difficult. It could also be that your body’s healthy weight is a little higher than what you’d like – which doesn’t mean you can’t lose, but makes it more difficult. If just eating Keto foods isn’t working, double check the macros for your weight and see if the amount you’re eating needs to be adjusted. You’ll find more help and support in our support group here.
One study assessed the effect of dietary interventions on quality of life, cognition and behavioural functioning, reporting participants in the KD group to be more active, more productive and less anxious after four months, compared to the control group. However, no significant difference was found in quality‐adjusted life years (QALYs) between the KD group and control group at four or 16 months (GRADE rating very low).
Dr. Luis Caicedo, a pediatric gastroenterologist and director of the Fecal Microbiota Transplant Program at Nicklaus Children's Hospital in Miami, who was not involved in the study, called the research "very exciting." It "opens the door for more investigations… and certainly gives you more data on why this ketogenic diet works so [well]" for epilepsy, Caicedo said.
Your current cholesterol levels l is higher than I would personally feel comfortable with. I would consider making a few dietary changes (i.e., increasing fiber and net carbs, reducing saturated fat, and increasing protein), especially given your lack of improved cognition and decreased ability to work out. I wish you the best of luck going forward. - Franziska
Leanne: Yeah, that’s amazing that you took your health into your own hands. I think that’s so empowering for so many people. When we just say “enough is enough and we need to change.” For me I came at this from the hormone piece, but also we have a strong line of dementia in our family. Very, very strong. For me, it was how can I be as good to my brain as possible? Not only is this good for your heart and everything else, but also looking at the health of your brain, which we talked about with having enough cholesterol is important for our brain function, too.
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The ketogenic diet may have a role in treating disorders of cellular proliferation, especially cancer. Just as chemotherapy selectively targets tumors based on differences in the way they divide compared with normal cells, investigators have proposed targeting tumors on the basis of differences in their metabolism. Normal tissue can adapt readily to using ketones (instead of glucose) as a substrate, but malignant cells probably do not have the same degree of metabolic flexibility [23]. One case report in 1995 [24, Class III] described the use of the ketogenic diet in two girls with advanced astrocytomas, based on the idea that brain tumors are less able than healthy brain tissue to use ketones as an energy source. In this report, PET studies demonstrated a 20% reduction in glucose uptake by the tumors following the initiation of the ketogenic diet. One of the patients actually showed improvement during the course of the study and has continued to be well, without evidence of tumor progression (T. Seyfried, personal communication, 2008).
Take your stress hormone cortisol: It stays highest in the morning and gradually tapers throughout the day. Measuring cortisol in the morning might yield an entirely different result from testing in the evening. Researchers speculate ketogenic diets might raise this stress hormone, but many other factors also come into play here that may have nothing to do with your diet.
I'm reading this in disbelief. I feel kind of numb to be honest. I'm in collection for thousands because of all the medical treatments, surgeries, and travel. For nearly 8 years my wife has worked two and sometimes 3 jobs and every time I was well enough I worked two jobs trying to catch up and still we fell behind. Call it pride or stupidity, but we never asked for help of any kind. I take care of older neighbors and spend much of my free time working with disabled veterans. I feel like I've given everything I had to help others my whole life. Thank You one and all!
Between 5 and 10 percent of women in the United States have polycystic ovary syndrome (PCOS), a disorder characterized by insulin resistance, menstrual irregularities, hyperandrogenism, overweight, and obesity. (15) A ketogenic diet improves fertility in women with PCOS by improving insulin resistance, promoting weight loss, and inducing ovulation. (16)

In a recent meta-analysis, eight studies were identified that used the MAD in adult patients with refractory epilepsy, aged between 15 and 86 years, with treatment times ranging from 3 to 36 months. In these studies, the proportion of patients who showed >50% seizure reduction ranged from 20 to 70% and the rate of seizure freedom ranged from 7 to 30%. The rate of abandonment of the diet varied between 12.5 and 82% of the patients (Liu et al., 2018).


It is very interesting to read about the keto/low card diet.I love to change my lifestyle as I an TYPE 2 Diabetic.I subscribed for a free printable low carb meal .The initial email stated that that I will receive an email for instructions to access the members area .Your free download will be there.However it is very deceiving ,I never got the 2nd email with instructions which is frustrating and not good .Hopefully this is not a way to get us to pay to get the printable version.

Ive been strict keto for over 3 months and have lost 20lbs. I got my test results back yesterday and was shocked to see how my levels had changed: total cholesterol went from 230 to 308!! All the bad went up and all the good went down. But I’ve also heard that it can take a bit longer for cholesterol levels to even out and start going down. Is this true? I don’t want to quit keto because I have another 20lbs to lose, but I don’t want to have a stroke either.

The first few days of keto can be difficult as your body adjusts to a low carbohydrate intake; you may experience symptoms such as brain fog, headache, insomnia, irritability, and digestive issues. These symptoms are commonly referred to as the “keto flu” and are caused by the glycogen loss, low insulin levels, and dehydration that frequently occur when you suddenly cut back on carbs. Know that these symptoms will pass, especially if you make sure to drink plenty of water, replenish your electrolyte levels, and eat sufficient protein and calories. At the most, it may take a couple weeks for the keto flu to subside, but for most people, this uncomfortable period passes within a few days.
Carbohydrates have been linked to this skin condition, so cutting down on them may help. And the drop in insulin that a ketogenic diet can trigger may also help stop acne breakouts. (Insulin can cause your body to make other hormones that bring on outbreaks.) Still, more research is needed to determine exactly how much effect, if any, the diet actually has on acne. 
Because the ketogenic diet alters the body's metabolism, it is a first-line therapy in children with certain congenital metabolic diseases such as pyruvate dehydrogenase (E1) deficiency and glucose transporter 1 deficiency syndrome,[35] which prevent the body from using carbohydrates as fuel, leading to a dependency on ketone bodies. The ketogenic diet is beneficial in treating the seizures and some other symptoms in these diseases and is an absolute indication.[36] However, it is absolutely contraindicated in the treatment of other diseases such as pyruvate carboxylase deficiency, porphyria, and other rare genetic disorders of fat metabolism.[9] Persons with a disorder of fatty acid oxidation are unable to metabolise fatty acids, which replace carbohydrates as the major energy source on the diet. On the ketogenic diet, their bodies would consume their own protein stores for fuel, leading to ketoacidosis, and eventually coma and death.[37]
The patient’s wife, a former college professor with an interest in nutritional medicine, learned about our approach from an article she read in an alternative health journal, and in the fall of 1991 he began treatment with me. Some fifteen months later, repeat CT scans showed stabilization of disease. Since he felt fine at the time, following his program religiously, he decided against any further conventional testing until 1998, seven years after he had started with me, when a series of CT scans confirmed total resolution of his once extensive cancer.
Polycystic Ovary Syndrome – Since PCOS shares many symptoms and underlying causes with metabolic syndrome, it has been hypothesized that women suffering from PCOS might benefit from a ketogenic diet in a similar fashion to those suffering from metabolic syndrome. One small pilot study of overweight and obese women with PCOS following a low-carbohydrate, ketogenic diet for six months saw significant improvements in many markers of the disease, such as free testosterone, and fasting insulin.43
Yes you can lose fat on a low carb because it’s just another low calorie diet. How do I know this? I’ve done low carb, (Atkins, etc) high carb, (Slimming Word) moderate carb etc and log my food and was shocked each time to see they were all low calorie. After the initial week or so the rate of fat loss is same as any other diet. It’s calories in calories out. Simple. It’s what some call indirect deficit diet placing silly restriction, rules can eat must eat etc. and of course you lose weight but nothing to do with low carb. It works because it’s a low calorie diet.
It is important to emphasize, however, that the ketogenic diet had a variable response. Some patients were able to comply with it better than other patients were. Additionally, of those that completed the trial, some had changes that are more favorable in certain parameters such as CRP. This suggests that the ketogenic diet is not suitable for everyone.
Your glycogen stores can still be refilled while on a ketogenic diet. A keto diet is an excellent way to build muscle, but protein intake is crucial here. It’s suggested that if you are looking to gain mass, you should be taking in about 1.0 – 1.2g protein per lean pound of body mass. Putting muscle on may be slower on a ketogenic diet, but that’s because your total body fat is not increasing as much.5Note that in the beginning of a ketogenic diet, both endurance athletes and obese individuals see a physical performance for the first week of transition.

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Leigh Tracy, RD, a dietitian and certified diabetes educator at The Center for Endocrinology at Mercy Medical Center in Baltimore, also advised people to remember that the study did not focus on whether or not the keto diet prevented or inhibited cancer growth — only on changes to the body including the fact that the diet reduced that patients’ central body fat, improved insulin levels, and improved lean body mass.
Whatever the source of protein you consume, make sure they are organic grass fed and antibiotic-free, as they are generally healthier and safer for your body. In one study, researchers indicated that grass fed beef (regardless of cuts) contains more omega-3 acid and conjugated linoleic acid compared to grain-fed beef.21 As for non-meat sources of protein, try to look for organic and pesticide-free varieties.
In contrast, some pathologies are considered contra-indicated for KD. Absolute contraindications have been described and summarized by Kossoff et al. (2018) (Table 3). The surgical epilepsies, whenever the patient or caregivers are having difficulty maintaining compliance with the diet, are relative contra-indications for KD (Table 4) (Kossoff et al., 2018).
The nutritional world then, as it is today, was surely confusing, with various scientists, physicians, and lay authors promoting one diet or another, often – as in the case of Atkins and Pritikin – offering completely contradictory dietary recommendations. Fortunately, when in 1987 Dr. Atkins offered me a job, I had already found what I thought represented a solution to the dilemma of dueling dietary dogma.

LDL is often referred to as “bad” cholesterol because high levels have been linked to increased heart disease risk. By contrast, HDL is frequently called “good” cholesterol. One of HDLs main functions is to carry cholesterol back to the liver to be used as needed. Higher levels of HDL have been associated with decreased cardiovascular disease (CVD) risk.

This equates to about 20 grams of carbohydrates on a 2000 kcal diet per day – a more stringent application of carbohydrate restriction use than the meta-analysis above. The second group consumed primarily a low-fat diet with 46%, 24%, and 30% energy from respectively from carbohydrate, protein, and fat per day. Both diets contained an equal number of calories.
You can still eat plenty of healthy dietary fats and also include gut-healing foods like leafy and cruciferous greens, prebiotic-rich foods like garlic and dandelion greens, and probiotic rock stars including kimchi and unpasteurized sauerkraut. Even with a daily 50-gram carb allowance, you can find a lot of anti-inflammatory, gut-supporting foods.
Dr. Gonzalez and his colleague Dr. Linda Isaacs MD have had remarkable success treating cancer patients with a non-toxic nutritional protocol that incorporates some of the principles of the late Dr. Max Gerson MD along with the late Dr. William Donald Kelley’s protocol which includes high doses of pancreatic enzymes and individualized diets depending on body type and cancer type. I have huge respect for them, not because of their theories, but because they are getting RESULTS, including reversing “incurable” stage four cancers. Two volumes documenting 112 of their successful case studies can be found here.
You may be given a diary to record the number and type of seizures you or your child has while on the diet. As food can affect how we feel or act, you may be asked to note any changes in your or your child’s mood, alertness and overall behaviour. It usually takes at least three months to see whether the diet is effective. The length of time the diet is followed may vary, but if an individual remains seizure-free, has fewer seizures, or maintains other benefits, such as improved quality of life, they may consider (with their medical team), slowly coming off the diet after two years.
HDL cholesterol transfers the extra cholesterol from the blood to the liver for removal from the body and is also referred to as “good” cholesterol. LDL cholesterol transfers the cholesterol within the bloodstream to the parts of the body where cell repair is needed and also inside the arteries. It is also known as “bad” cholesterol. Total cholesterol is HDL and LDL cholesterol combined (4).
You can change that genetics. I can’t change the genetic tendency, it’s going to be there. By golly, I’m going to pay attention to everything that I put in my mouth for that sake alone. Anyone with that kind of history, I don’t think it’s reason to freak out. I don’t think it’s a reason to think it’s an inevitability for you. It’s just one of those things that you have to pay attention to all of your numbers, anal retentively. That’s why I pay attention to my HSCRP so closely, that’s why I run my numbers so often. I know I have that tendency. I probably, had I not lost the 180 pounds in 2004, I would be in an early grave just like my brother.
For patients who benefit, half achieve a seizure reduction within five days (if the diet starts with an initial fast of one to two days), three-quarters achieve a reduction within two weeks, and 90% achieve a reduction within 23 days. If the diet does not begin with a fast, the time for half of the patients to achieve an improvement is longer (two weeks), but the long-term seizure reduction rates are unaffected.[44] Parents are encouraged to persist with the diet for at least three months before any final consideration is made regarding efficacy.[9]
This review aimed to investigate the effect of ketogenic diets on seizure control, cognition (e.g. learning, concentration and academic performance in children; learning, concentration and memory in adults) and behaviour. We also investigated the side effects of the diet and the number of participants who dropped out of the studies and the reasons for this.

Over the past two years Feldman, a software engineer with a strong interest in science, has performed several dozen experiments on himself and collected data from a number of other keto and low-carb dieters whose cholesterol levels have increased far beyond the “optimal” range. However, whether this is problematic or not isn't entirely clear, especially since their other biomarkers typically improve or remain stable.

On the ketogenic diet, carbohydrates are restricted and so cannot provide for all the metabolic needs of the body. Instead, fatty acids are used as the major source of fuel. These are used through fatty-acid oxidation in the cell's mitochondria (the energy-producing parts of the cell). Humans can convert some amino acids into glucose by a process called gluconeogenesis, but cannot do this by using fatty acids.[57] Since amino acids are needed to make proteins, which are essential for growth and repair of body tissues, these cannot be used only to produce glucose. This could pose a problem for the brain, since it is normally fuelled solely by glucose, and most fatty acids do not cross the blood–brain barrier. However, the liver can use long-chain fatty acids to synthesise the three ketone bodies β-hydroxybutyrate, acetoacetate and acetone. These ketone bodies enter the brain and partially substitute for blood glucose as a source of energy.[56]
The first edition of this book was released in 2012 and was the first book written to help the patient. It has been updated as the research has developed, and the body of scientific evidence continues to grow. Metabolic therapy is cutting edge, and thousands of people have purchased and used the information in this book to take back some control over their own health. You can too.
Note: Are you a vegetarian or vegan and want to go on a ketogenic diet? It’s still possible! Just keep in mind that the dietary restrictions can sometimes be a little bit intense. Make sure to plan ahead and prepare to aid your success. To help out, we’ve published articles (with 7 day meal plans included) for both the vegetarian ketogenic diet and the vegan ketogenic diet.

She learned about Kelley’s work, began the program, regained her health, and avoided all conventional doctors for many years. In 1984, nine years after coming under Kelley’s care, she returned to her primary care physician who was quite perplexed she was still alive after all this time. A chest x-ray showed total resolution of her once widespread lung metastases.

Nonetheless, enthusiastic oncologists joined with the media, portraying insurance companies as heartless, greedy bullies depriving women with breast cancer of a curative treatment. Not too long after, the trial lawyers got involved, orchestrating a series of lawsuits against various insurance companies on behalf of women wanting a BMT. In a particularly notable and telling case, Fox vs. HealthNet, the jury awarded the plaintiff, a woman diagnosed with breast cancer whose insurance carrier refused to cover the procedure, $89 million, including $77 million in punitive damages.
In addition to neuroblastoma, various researchers have investigated the efficacy of KDs as an adjuvant therapy for other types of cancer. The strongest evidence (> 3 studies) for a tumor-suppressing effect has been reported for glioblastoma, whereas little or no benefit was found for two other brain tumors (astrocytoma and medulloblastoma). Good evidence (2 - 3 studies) is available for prostate, colon, pancreatic and lung cancer [1]; neuroblastoma also falls into this category (Figure 1). Some of those studies report a tumor-suppressing effect of KD alone and/or in combination with classic therapy and/or caloric restriction. One study on prostate cancer applied the KD in a preventive, instead of a therapeutic, study setting. Only limited evidence (1 study) supports the anti-tumor effect of an unrestricted KD on breast, stomach, and liver cancer.

Your child may start the diet in the hospital, so nurses and doctors can observe the first few days. Your child will probably need to go without any food for 36 to 48 hours before beginning the diet. After that, food is gradually increased over a few days. This diet does not provide all the vitamins a body needs, so your child will probably have to take sugar-free vitamin supplements.


Though most of our cells can utilize fatty acids of all stripes via beta oxidation to create ATP energy, our central nervous system is at somewhat of a disadvantage. In fact, long chain fatty acids with 14 or more carbons, which can yield the most ATP from beta oxidation, do not cross the blood-brain barrier. However, in a state of prolonged dietary carbohydrate depletion, the liver begins converting acetyl coenzyme A into various ketone bodies, such as acetoacetate and beta hydroxy butyric acid, which easily penetrate into the brain and which can, like acetyl coenzyme A, be shunted into the citric acid cycle and then the electron transport chain, providing the brain with ATP.
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