A recent 2018 online survey of type 1 diabetics or their parents and caregivers has opened the door for others to use the ketogenic high-fat, low-carbohydrate, moderate protein diet to ease the burden of insulin injections and improve the day-to-day life of type 1 diabetics, potentially leading to remission. This was a breakthrough study, as the ketogenic diet has proven itself with diabetes type 2 sufferers, but there has been little looked into with keto for diabetes 1 patients. This study's focus was on serious carb production. Its title is Management of Type 1 Diabetes With a Very Low–Carbohydrate Diet, and it was published by Pediatrics, the "official journal" of the AAP (American Academy of Pediatrics). Dr. Lewis First, chief editor of Pediatrics, provided an article listing the top 10 items published by Pediatrics during 2018. This study was at the top of the list as the most popular article in Pediatrics for 2018.
Our normal healthy cells, be they situated in the brain or the skin of our feet, do prefer glucose as their primary energy source, obtained from the sugar circulating in the blood. That “blood sugar” comes from a variety of sources, including dietary carbohydrates occurring in fruits, starchy vegetables like potatoes, and grains. The complex carbohydrates in such foods are broken down into glucose during the digestive process, catalyzed by a variety of carb-specific enzymes like amylase.
Everyone talks about upping their fats… I do not think that is the key to sweeping LDL out of the system. Upping cruciferous fiberous veggies… the fiber, vitamins and minerals contained in veggies bind with the LDL and move it on out. You would have to eat literally a truck load to make any serious dent in your daily carb allowance since most are very low net carb anyways.
Vegan ketogenic diet or vegetarian diet: Yes, both are possible. Instead of animal products, plenty of low-carb, nutrient-dense vegan and/or vegetarian foods are included. Nuts, seeds, low-carb fruits and veggies, leafy greens, healthy fats and fermented foods are all excellent choices on a plant-based keto diet. There’s also a similar plan called ketotarian, which combines keto with vegetarian, vegan and/or pescatarian diets for supposedly greater health benefits.
The ketogenic diet keeps this process going. It forces the child’s body to burn fat round the clock by keeping calories low and making fat products the primary food that the child is getting. In fact, the diet gets most (80 percent) of its calories from fat. The rest comes from carbohydrates and protein. Each meal has about four times as much fat as protein or carbohydrate. The amounts of food and liquid at each meal have to be carefully worked out and weighed for each person.
Cyclical ketosis means you’re sometimes in ketosis and sometimes aren’t. A few days each week—the night before workout days to build glycogen stores in your muscles—try increasing your intake of berries, higher complex carb veggies (like sweet potatoes), and non-gluten grains. It might knock you out of ketosis temporarily, but it also provides a wealth of nutrients to keep you lean, healthy, and happy. This is also called flexible ketosis, which creates metabolic flexibility—the holy grail of metabolism management. I’ve also talked about cycling ketosis with intermittent fasting, which provides a win-win strategy to reach your health goals.
Growth Factor Suppression. The ketogenic diet suppresses insulin-like growth factor (IGF-1). This molecule is associated with the formation and progression of cancerous cells. It is “upregulated” when you eat more carbohydrates, making it more likely to trigger cancer growth. Because the ketogenic diet is much lower in carbohydrates, scientists suspect that this suppresses IGF-1 production. This ultimately slows the formation of cancerous cells.
An overwhelming majority (90%) of parents said that they would. Even though the keto diet is extremely restrictive, time consuming, and requires rigid maintenance, most parents found the potential benefits outweighed its drawbacks. Many parents in the study were more concerned about the side effects of the medications―and were grateful for the opportunity to explore an alternative option. Further, 55% would consider trying the diet again.
The oxygen-free pathway used by cancer cells needs a lot more glucose to produce the same amount of energy as an oxygen-using cell. This realization led to imaging techniques where cancer cells can be detected by spotting where large amounts of a glucose tracer accumulate in the body. The glucose used in this technique contains a small amount of radioactive material that lights up in the image.
The second is called LDL-P which measures the number of LDL particles in the blood. Sometimes, there is a correlation – more LDL particles means that you can have higher levels of LDL-C. However, larger LDL molecules can grow and carry more cholesterol – leading to a discordance in which LDL-C and LDL-P are not necessarily proportional. When this happens, LDL-C and LDL-P are said to be “discordant.”
Neurological Function– A ketogenic diet may be neuroprotective since it increases energy production in the brain, limits the production of free radicals, limits neuronal excitability and increases production of GABA in the brain.27 28 Researchers have hypothesized that a ketogenic diet and, in particular, ketones might benefit neurological function in several conditions and situations, including Alzheimer’s, Parkinson’s, Friedreich’s ataxia, autism and traumatic brain injury. 29 30 In Alzheimer’s disease, it appears that brain cells become unable to use glucose for energy production; a ketogenic diet can provide an alternative fuel for the brain. 31 Several studies have found that giving patients with mild to moderate Alzheimer’s medium chain triglycerides (MCTs), a type of fat that is readily accessible for ketone formation, improves cognition, but the effects are more pronounced in those that do not carry the APOE e4 gene variant that is associated with increased risk of Alzheimer’s.32 33 34 Research is just beginning to explore these conditions, and a better understanding of how effective the ketogenic diet is in treating certain neurological conditions will likely be available in the near future.
Keto will increase your cholesterol, because your body is getting more cholesterol from food. So guess what your body will do when you increase the dietary cholesterol…that’s right, it’ll stop producing its own cholesterol. Since 75% of your cholesterol is made inside your body, if you increase the amount that you eat, your body will cut that 75% down. Your body isn’t stupid. It knows what it needs.
• High-protein ketogenic diet — This method is a variant of the SKD. In a high-protein diet, you increase the ratio of protein consumption to 10 percent and reduce your healthy fat consumption by 10 percent. In a study involving obese men that tried this method, researchers noted that it helped reduce their hunger and lowered their food intake significantly, resulting in weight loss.11
Aside from carb flu, be warned that staying in long-term, continuous ketosis may have drawbacks that may actually undermine your health and longevity. To stay on the safe side, I recommend undergoing a cyclic ketogenic diet. The "metabolic magic" that ketosis brings to the mitochondria actually occurs during the refeeding phase, not during the starvation phase.
Treatment with MAD was shown to be more effective in seizure control when the MAD was started with lower carbohydrate limits (Kossoff et al., 2010). In a randomized study with 20 children with drug-resistant epilepsy, 60% of them showed fewer seizures in the first 3 months on the MAD, with 10 g/day of carbohydrate intake against 10% of reduction with 20 g/day (p = 0.03). In the same study, after 3 months, an increase in carbohydrate intake to 20 g/day, maintained seizure control and improved tolerability, suggesting that a lower carbohydrate limit is important only in the first 3 months (Kossoff et al., 2007; Kossoff and Dorward, 2008).
The first edition of this book was released in 2012 and was the first book written to help the patient. It has been updated as the research has developed, and the body of scientific evidence continues to grow. Metabolic therapy is cutting edge, and thousands of people have purchased and used the information in this book to take back some control over their own health. You can too.
Frederick F. Samaha, M.D., Nayyar Iqbal, M.D., Prakash Seshadri, M.D., Kathryn L. Chicano, C.R.N.P., Denise A. Daily, R.D., Joyce McGrory, C.R.N.P., Terrence Williams, B.S., Monica Williams, B.S., Edward J. Gracely, Ph.D., and Linda Stern, M.D., “A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity,” N Engl J Med 2003; 348:2074-2081. http://www.nejm.org/doi/full/10.1056/NEJMoa022637.
The initial pronouncements, released with such glowing enthusiasm, indicated that finally, yes finally, after so many disappointments we might actually be looking at a real, universal cancer cure. In both laboratory and preliminary human trials, interleukin-2 – like interferon before it, a natural product secreted by lymphocytes that stimulates other cancer-fighting immune cells into action – had performed almost magically against even the most aggressive of cancers, such as metastatic melanoma and metastatic kidney cancer.
Recently, many of my patients have been asking about a ketogenic diet. Is a ketogenic diet safe? Would you recommend it? Despite the recent hype, a ketogenic diet is not something new. In medicine, we have been using it for almost 100 years to treat drug-resistant epilepsy, especially in children. In the 1970s, Dr. Atkins popularized his very-low-carbohydrate diet for weight loss that began with a very strict two-week ketogenic phase. Over the years, other fad diets incorporated a similar approach for weight loss.
Bulk buy and cook. If you’re someone who doesn’t like to spend a lot of time in the kitchen, this is the best of both worlds. Buying your food at bulk (specifically from wholesalers) can reduce the cost per pound tremendously. Plus, you can make ahead food (bulk cook chicken thighs for pre-made meat, or cook entire meals) that are used as leftovers, so you spend less time cooking.
Leanne: I went to my naturopath, and she’s like this is awesome, this is exactly what we want to see. My issue was hormones, so I want cholesterol so that my body can build hormones, because without that cholesterol good luck. When I went to my regular GP, he was like “Statins, put you on statins. Oh my gosh it’s way too high.” What do you say to people, you’re saying 200 is always thrown out there with cholesterol. What you’re saying is that cholesterol is not really all that important in the grand scheme of things if you’re looking at your number. It’s more important to look at triglycerides in that ratio?
His research and clinical practice focuses on the diagnosis and treatment of childhood seizures and epilepsy, particularly treatments other than medications such as diet, neurostimulation and surgery. Currently the Medical Director of the Ketogenic Diet Center at Johns Hopkins, he is a world expert on the ketogenic diet and created the modified Atkins diet for children and adults in 2003. He is dedicated to bringing the use of diet therapies for neurologic disorders to the entire world and is the head of a Task Force within the International League Against Epilepsy to help achieve this goal. He is a coauthor of The Ketogenic and Modified Atkins Diets: Treatments for Epilepsy and Other Disorders, now in its 6th edition. Dr. Kossoff is also published in the fields of Sturge-Weber syndrome, migraine and epilepsy, infantile spasms, Doose syndrome, and benign rolandic epilepsy.
The ketogenic diet has been shown in many studies to be particularly helpful for some epilepsy conditions. These include infantile spasms, Rett syndrome, tuberous sclerosis complex, Dravet syndrome, Doose syndrome, and GLUT-1 deficiency. Using a formula-only ketogenic diet for infants and gastrostomy-tube fed children may lead to better compliance and possibly even improved efficacy.
Throughout his talks, both here and elsewhere, Dr. Seyfried presents mouse studies that are interesting and suggestive that there might be something to this whole ketogenic diet thing, at least in brain tumors, such as this one. However, this is what we in the oncology biz would call pretty preliminary data, worthy of further investigation but not supporting the grandiose claims that Dr. Seyfried makes.
I’m not going to shell out 20k to know my LDL-P. I’d rather assume that I’m part of the 30% who reacts to saturated fat with elevated LDL-P. Should I be worried, considering all my other markers point to the right direction? Expert after expert say that we don’t know what these mixed signals mean until there is a study of people doing low-carb high-fat diets, correlating their lipid profiles with incidence of cardiovascular disease.
There are many ways in which epilepsy occurs. Examples of pathological physiology include: unusual excitatory connections within the neuronal network of the brain; abnormal neuron structure leading to altered current flow; decreased inhibitory neurotransmitter synthesis; ineffective receptors for inhibitory neurotransmitters; insufficient breakdown of excitatory neurotransmitters leading to excess; immature synapse development; and impaired function of ionic channels.
One dubious practice of some keto diet adherents is using urine, blood or breath test kits to check their circulating ketone levels. While those kits can tell you if your body is indeed burning ketones instead of glucose, Westman says there’s no good evidence that one ketone level is better than another. “The level of water in a stream doesn’t necessarily tell you how much water is flowing through it,” he says. “In the same way, measuring the level of ketones in the blood doesn’t tell you the whole story.”
Fasting continues until dinner on day 1 of the admission. At this time, half of the calculated diet is provided as an ‘eggnog’ (or ketogenic formula). A ketogenic eggnog looks and tastes like a milkshake and can be sipped, frozen as ice cream, or cooked as scrambled eggs. Excess ketosis at this time, which may cause vomiting, can be relieved with a small amount of orange juice. Once the child begins eating, serum glucose checks are unnecessary and are discontinued.
I knew Bob quite well, and considered him a friend. We first met when I interviewed him for a nutrition story during my journalism days, and later on while I was a medical student, we kept in close contact. During my freshman year at Cornell Medical School – from which Bob had received his own medical degree – I arranged for him to speak as part of a lecture series I had set up on alternative approaches to disease.
Once the body is adapted to ketosis, constipation and/or diarrhea are the most commonly reported side effects along with increased urination. Continuing to keep your mineral intake high and ensuring adequate water and fiber intake will help to counter these effects. People in ketosis may also notice a sweet or fruity odor on their breath, which is the result of increased production of the ketone acetone, which is a very volatile compound that is eliminated mainly through respiration in the lungs. 50
Leanne: Yeah. My HDL from eating plant-based … before I started this, so I was eating a ton of plants … my HDL was 86. Now it’s 108. It’s increased since eating high fat. Everyone says, “How is it even possible because you’re not…” Then my triglycerides before were 37 and now they’re 59, so they were really low. In fact, my doctors were like, “Okay Leanne, you really actually need to increase your LDL and triglycerides.” When I was eating plant-based because even my LDL was like 48, it was too low.
While I would like to offer a magic bullet for all cancers, a ketogenic diet is not that. The diet does not “cure” cancer. It should not be used to replace traditional treatment. But the diet has shown promise for some cancers especially GBM. So why would a diet help? On a simplistic level, cancer “eats” glucose and needs 20 times more glucose compared to normal cells. Cancer cells cannot make the transition to using ketones, especially in the brain, making them more vulnerable to chemo and radiation.
A computer program such as KetoCalculator may be used to help generate recipes. The meals often have four components: heavy whipping cream, a protein-rich food (typically meat), a fruit or vegetable and a fat such as butter, vegetable oil, or mayonnaise. Only low-carbohydrate fruits and vegetables are allowed, which excludes bananas, potatoes, peas, and corn. Suitable fruits are divided into two groups based on the amount of carbohydrate they contain, and vegetables are similarly divided into two groups. Foods within each of these four groups may be freely substituted to allow for variation without needing to recalculate portion sizes. For example, cooked broccoli, Brussels sprouts, cauliflower, and green beans are all equivalent. Fresh, canned, or frozen foods are equivalent, but raw and cooked vegetables differ, and processed foods are an additional complication. Parents are required to be precise when measuring food quantities on an electronic scale accurate to 1 g. The child must eat the whole meal and cannot have extra portions; any snacks must be incorporated into the meal plan. A small amount of MCT oil may be used to help with constipation or to increase ketosis.
Insulin is a hormone that lets your body use or store sugar as fuel. Ketogenic diets make you burn through this fuel quickly, so you don’t need to store it. This means your body needs -- and makes -- less insulin. Those lower levels may help protect you against some kinds of cancer or even slow the growth of cancer cells. More research is needed on this, though.
One notes that the patient who didn’t survive 12 months wasn’t much mentioned; so I assume she didn’t demonstrate any clinical improvement. In any case, this study doesn’t really show anything, other than that a ketogenic diet might decrease glucose uptake in some brain tumors. It’s like a Burzynski case report, in which we have no idea whether the patient did better than expected because of the intervention or because she had less aggressive disease.
The ketogenic diet is a natural, nontoxic metabolic therapy being studied and utilized for cancer prevention and treatment. It works because cancer cells are dependent upon a constant supply of blood sugar (glucose) to stay alive. Normal cells can make energy from both glucose and ketones (metabolic by-products of burning fat), but most cancer cells can only use glucose. Avoiding carbohydrates (starch and sugar) while enjoying delicious and healthy protein and fats will lower blood glucose and increase blood-ketone levels, resulting in a normal body state called nutritional ketosis. Research has shown that nutritional ketosis starves cancer cells while nourishing normal cells and strengthening total body health.
The biggest shifts in your daily habits will be how you food shop and how you cook, and recipes that are ketogenic need to be followed rather than just low-carb. You will require the healthy fats in order to get into ketosis and have enough energy without the carbs. And you will be considerably more energetic and healthier when cooking your own keto-friendly food rather than buying supposedly keto foods off the shelf.
Epilepsy is a disorder where recurrent seizures (fits) are caused by abnormal electrical discharges from the brain. In most people seizures can be controlled by one or more antiepileptic medicines, but seizures may not be helped by these medicines after a while (called drug‐resistant epilepsy). For people who have drug‐resistant epilepsy, a special diet (called a ketogenic diet) may be considered. Ketogenic diets are high in fat and low in carbohydrate.
Certain studies suggest that keto diets may “starve” cancer cells. A highly processed, pro-inflammatory, low-nutrient foods can feed cancer cells causing them to proliferate. What’s the connection between high-sugar consumption and cancer? The regular cells found in our bodies are able to use fat for energy, but it’s believed that cancer cells cannot metabolically shift to use fat rather than glucose. (11)
Most condiments below range from 0.5–2 net carb grams per 1–2 tablespoon serving. Check ingredient labels to make sure added sugar is not included, which will increase net carbs. (Stevia and erythritol will become your go-to sweeteners because neither raise your blood sugar — combine for a more natural sweet taste and, remember, a little goes a long way!)
Dr. Josh Axe, DNM, DC, CNS, is a doctor of natural medicine, clinical nutritionist and author with a passion to help people get well using food as medicine. He’s the author of the books “Eat Dirt: Why Leaky Gut May Be the Root Cause of Your Health Problems,” “Essential Oils: Ancient Medicine” and the upcoming “Keto Diet: Your 30-Day Plan to Lose Weight, Balance Hormones, Boost Brain Health, and Reverse Disease” (February 2019, published by Little, Brown Spark). He’s a co-founder of Ancient Nutrition, a health company where the mission is to restore health, strength and vitality by providing history’s healthiest whole food nutrients to the modern world.
Children who discontinue the diet after achieving seizure freedom have about a 20% risk of seizures returning. The length of time until recurrence is highly variable, but averages two years. This risk of recurrence compares with 10% for resective surgery (where part of the brain is removed) and 30–50% for anticonvulsant therapy. Of those who have a recurrence, just over half can regain freedom from seizures either with anticonvulsants or by returning to the ketogenic diet. Recurrence is more likely if, despite seizure freedom, an electroencephalogram shows epileptiform spikes, which indicate epileptic activity in the brain but are below the level that will cause a seizure. Recurrence is also likely if an MRI scan shows focal abnormalities (for example, as in children with tuberous sclerosis). Such children may remain on the diet longer than average, and children with tuberous sclerosis who achieve seizure freedom could remain on the ketogenic diet indefinitely.
It’s not heart healthy because it’s raising inflammation. The reason they put in on there though is it does one thing on your cholesterol panel that they think is good. It lowers the LDLC number. It does. It will do it all day everyday. You can sit there and drink Canola oil, and your LDL will go down, your LDLC. That LDLC is just a calculated number using this thing called the Friedewald equation and it’s not directly measured. That’s another thing people don’t realize. LDLC is just totally an estimated number. When your triglycerides are under 100 and your HDL is over 50, it totally miscalculates what your LDL is. That’s why that NMR lipo profile test to know the particles is so important. I know I’m talking fast and saying a lot of technical terms.
We searched medical databases for randomised controlled trials (clinical studies where people are randomly put into one of two or more treatment groups) of adults or children with epilepsy, where a ketogenic diet was compared with other treatments. We found 11 randomised controlled trials, with 778 participants. The trials were between two and 16 months long.
Dr. Seyfried does include a chapter toward the book’s end entitled “Case Studies and Personal Experiences in using the Ketogenic Diet for Cancer Management.” Here, Dr. Seyfried provides a description of a pilot study, written by the investigators themselves, discussing the use of the ketogenic diet in children with inoperable brain cancer. However, the authors admit the study was intended only to evaluate the diet’s tolerability and effect on glucose metabolism as determined by PET scanning, not treatment benefit or survival.
In order to be successful, this therapy calls for strict compliance and plenty of patience, especially in the beginning. Most important, patients with epilepsy should only use the diet with the support of a knowledgeable ketogenic diet team, including a doctor and a licensed dietitian who can correctly calculate and monitor the diet for each individual.
The mbg Collective is a curated group of our most trusted wellness advisers. Since 2009, we’ve had the brightest, most passionate, and mission-driven leaders in wellness share their intimate stories and world-class advice. Now, we’re giving you unparalleled access to the people who, alongside mbg, are putting the “WE” back in wellness. Consider them your personal guides, there to support you and sustain you on your journey.