Leanne: Yeah, that believed in coconut from the very beginning and they didn’t go on this campaign of ridding it from the earth. I’m totally pro coconut oil and saturated fat. It’s been so great chatting with you about this cholesterol piece. I hope that a lot of our listeners, watchers, readers are going to benefit from the information that you’ve shared. If they want to know more about you Cholesterol Clarity is awesome. Keto Clarity is great. Your podcast, just download every single podcast Jimmy’s ever made. It will keep you busy for the next two years.
Leanne: Billion. Okay, let’s talk a little bit about Staten, I can’t remember what book it was but they were saying that cholesterol is really important for brain health. You mentioned that too, the cholesterol uses the nutrient and moves it up to your brain, it’s really important. What I was reading is that as we age our cholesterol actually increases slightly to help with that aging process. You often meet people that are in their 40s, 50s, I know a lot of people in my family are now on Staten because their cholesterol is increasing. I always say, “Maybe that’s your body’s way of protecting yourself against aging.”
For the latest update we searched the Cochrane Epilepsy Group's Specialized Register (11 April 2017), the Cochrane Central Register of Controlled Trials (CENTRAL) via the Cochrane Register of Studies Online (CRSO, 11 April 2017), MEDLINE (Ovid, 11 April 2017), ClinicalTrials.gov (11 April 2017) and the WHO International Clinical Trials Registry Platform (ICTRP, 11 April 2017). We imposed no language restrictions. We checked the reference lists of retrieved studies for additional reports of relevant studies.
The mainstay of treatment for epilepsy is pharmaceutical intervention. As I recently noted, more and more we are seeing surgical procedures being performed for those individuals who have not had a significant improvement with drugs. I indicated that at least some individuals are gluten sensitive and may benefit from a gluten-free diet which potentially could keep them from undergoing potentially life-threatening surgery as a treatment for their epilepsy.
Animal proteins (meat, fish, etc.) have very little, if any, carbs. You can consume them in moderate amounts as needed to control hunger. Overall, choose fattier cuts of meat rather than leaner ones. For example, chicken thighs and legs are preferable to chicken breasts because they contain much more fat. We’ve got quick keto diet chicken recipes to help.
Dr. Folkman had developed two drugs, angiostatin and endostatin, that in animal experiments reversed tumor growth by blocking new blood vessel formation, essentially starving out the cancer cells. In a November 1998, presentation of his work at the National Institutes of Health in Bethesda, Maryland, Dr. Folkman announced to the world that at least in mice, “we have not seen a tumor we cannot regress.”
In 1921, Rollin Turner Woodyatt reviewed the research on diet and diabetes. He reported that three water-soluble compounds, β-hydroxybutyrate, acetoacetate, and acetone (known collectively as ketone bodies), were produced by the liver in otherwise healthy people when they were starved or if they consumed a very low-carbohydrate, high-fat diet. Dr. Russell Morse Wilder, at the Mayo Clinic, built on this research and coined the term "ketogenic diet" to describe a diet that produced a high level of ketone bodies in the blood (ketonemia) through an excess of fat and lack of carbohydrate. Wilder hoped to obtain the benefits of fasting in a dietary therapy that could be maintained indefinitely. His trial on a few epilepsy patients in 1921 was the first use of the ketogenic diet as a treatment for epilepsy.
Sharon M. Nickols-Richardson, PhD, RD, , Mary Dean Coleman, PhD, RD, Joanne J. Volpe, Kathy W. Hosig, PhD, MPH, RD, “Perceived Hunger Is Lower and Weight Loss Is Greater in Overweight Premenopausal Women Consuming a Low-Carbohydrate/High-Protein vs High-Carbohydrate/Low-Fat Diet,” The Journal of Pediatrics: Vol 105, Issue 9: 1433–1437; September 2005. http://www.sciencedirect.com/science/article/pii/S000282230501151X.
The most convincing piece of evidence can be found in a 2003 meta-analysis. In this meta-analysis, researchers compiled the data from sixty trials that quantified the effect that feeding different types of fats to humans had on the total-to-HDL cholesterol ratio . But before we look through the results, we must first understand what this ratio is.
Seizure reduction can occur very soon after the ketogenic diet is initiated or it may take several months. During this time, it is important to remain committed to keeping the diet consistent and work with your keto diet team who will help you fine tune the diet to achieve the best seizure control. Commitment to consistency to the diet recommendations is important to determine effectiveness of the therapy in controlling seizures.
Cancer is not a single disease, but rather a group of diseases all of which share the common feature of abnormal cell growth. Cancer cells either stay put where they are formed or spread to other parts of the body. In the U.S. alone, it is estimated that nearly 2 million new cases of cancer will have been diagnosed in 2018, while over 600,000 people will have died as a consequence of this disease.7
It’s not clear just how a ketogenic diet works for seizures. But Yellen says seizures are like “electrical storms” in the brain. “There are potassium channels in the brain that, when open, seem to have a quieting influence on this electrical excitation,” he says. “We think these channels work better when the brain is using ketones instead of glucose for energy.” Even when epilepsy medications have failed, a ketogenic diet can work wonders, he says.
The role of gut microbiota has recently been studied for its effect on several diseases, especially those with some inflammatory involvement. Several metabolic pathways are known to be modulated by the gut microbiota. Olson et al. (2018) demonstrated the impact of gut microbiota on the anti-seizure effect of KD. She found that KD modifies the gut microbiota, with a decrease in alpha-diversity and increases in the putatively beneficial bacteria Akkermansia muciniphila and Parabacteroides spp. This microbiota transformation leads to changes in the colonic luminal metabolome, with a decrease in gamma-glutamyl amino acids. This increases the GABA/glutamate content in the brain by decreasing gamma-glutamyl amino acids in the blood (Olson et al., 2018). In an acute electroshock model, it is reported that KD confers protection against seizures. Moreover, KD decreases the frequency of spontaneous seizures in Kcna1 knockout mice (Kim et al., 2015). In summary, changes in the gut microbiota seem to be important for the KD-mediated seizure protection.
Similar results were reported by a telemedical guided weight loss program among 200 overweight adults, where triglyceride and HDL-cholesterol levels were lower at month 6 in the keto diet group compared to the low-fat group. The conclusion was that a low-carb diet has more benefits in reducing cardiovascular risks compared to the low-fat diet (12).
The CKD and its variants should be considered as an alternative for non-surgical pharmacoresistant patients with epilepsy, of any age. Each patient must have an individually designed diet; however, adult patients have more difficulty in maintaining the CKD. It is essential to inform the patient and the family about the efficacy and AE related to the KD, and the use of websites and videos may help in this education. Although several theories exist regarding the mechanisms of action, further study is needed nevertheless the positive results are probably due to several mechanisms.
Kossoff et al. (2018) proposed that dietary therapy should be considered earlier as an option for treatment of intractable epilepsy, because of its proven efficacy, the poor chance of improvement with further anticonvulsant administration, and the possibility of using the MAD (Kossoff et al., 2006) and low-glycemic-index treatment (LGIT) (Pfeifer and Thiele, 2005), which are easier to manage in adults.
This equates to about 20 grams of carbohydrates on a 2000 kcal diet per day – a more stringent application of carbohydrate restriction use than the meta-analysis above. The second group consumed primarily a low-fat diet with 46%, 24%, and 30% energy from respectively from carbohydrate, protein, and fat per day. Both diets contained an equal number of calories.
"It's called ketogenic metabolic therapy," and he says in this context, "the ketogenic diet shouldn't be considered a diet like green salads or other such stuff. It's essentially medicine, and the process primarily tries to remove one of the driving fuels for the disease, which is glucose, and transition the whole body over to ketones, which the tumor cells can't use as a fuel."
There is nothing inherently difficult about following a ketogenic diet. We have many patients who do this very easily over many years. The metabolic benefits significantly outway any perceived challenges from limiting particular food types. Uptake would be far more widespread if nutrition professionals left their predujical opinions of SFA’s behind. Finally, given the expertise in Ketogenic Diets at Harvard, Dr David Ludwig, for one springs to mind, I am surprised the author did not avail themselves of the local expertise.
Yes and there is also 1000s studies that are paid by the meat industry to say that meat is good. What u say is right BUT the meat industry is really messed up too. Super intensive production of really low quality beef is killing us and the planet. Watch cowspiracy/ and documentaries of the sort and then tell m the balk of the problem is not here.. or at least as big as sugar corporations
They also noted that some patients were more responsive to the ketogenic diet than other patients were. The best response was in a 3-year-old girl who had complete remission five years of treatment with a ketogenic diet. Two other patients also experienced complete remission after the diet, and the other two patients had disease progression after stopping keto. (Keep in mind, however, that all of these patients used conventional treatments along with the keto diet.)
Whatever the source of protein you consume, make sure they are organic grass fed and antibiotic-free, as they are generally healthier and safer for your body. In one study, researchers indicated that grass fed beef (regardless of cuts) contains more omega-3 acid and conjugated linoleic acid compared to grain-fed beef.21 As for non-meat sources of protein, try to look for organic and pesticide-free varieties.
If a person with familial hypercholesterolemia is then put on a high-fat diet, they will become even more vulnerable to heart disease as the increased saturated fat and cholesterol content of the diet provokes higher cholesterol levels. And it gets even worse — since this person lacks the ability to clear LDL cholesterol out of their blood normally — their cholesterol levels will stay elevated for an even longer period of time. This will make it much more likely that the LDL particles will become damaged and stimulate plaque build up in the blood vessels.
After some 40,000 women underwent the procedure – at a time when 10-30% of patients died from the treatment itself – it was eventually proven to be worthless. The one glowing positive study from 1995, the infamous South African study of Dr. Bezwoda, turned out on closer examination to be a complete fraud, with the creative researcher simply making up the data. The wonderful and frightening book False Hope describes the bone marrow transplant-breast cancer fiasco in great detail, for those with an interest.
Though most of our cells can utilize fatty acids of all stripes via beta oxidation to create ATP energy, our central nervous system is at somewhat of a disadvantage. In fact, long chain fatty acids with 14 or more carbons, which can yield the most ATP from beta oxidation, do not cross the blood-brain barrier. However, in a state of prolonged dietary carbohydrate depletion, the liver begins converting acetyl coenzyme A into various ketone bodies, such as acetoacetate and beta hydroxy butyric acid, which easily penetrate into the brain and which can, like acetyl coenzyme A, be shunted into the citric acid cycle and then the electron transport chain, providing the brain with ATP.
Hi Kelly, All packaged foods will have a nutrition label that list the macros per serving, including fat, protein and cabrohydrates. Net carbs, which is what most people look at for low carb and keto, are total carbs (the amount on the label) minus fiber and sugar alcohols, as explained in the article above. I have a low carb food list here that gives you a full list of all the foods you can eat, and the net carbs in each. You can also sign up above to be notified about the meal plans, which are a great way to get started.
By contrast, some people have seen their total, HDL and LDL cholesterol levels increase anywhere from 50% to 200% or more after switching to a low-carb or keto diet. Although a few are overweight or metabolically unhealthy, many of these individuals belong to a group that Dave Feldman at Cholesterol Code calls Lean Mass Hyper-responders (LMHRs): healthy, thin and/or athletic people with LDL cholesterol values of 200 mg/dL (5.2 mmol/L) or higher.
The understanding of the mechanisms of action of KD is incomplete; however, some theories have been advanced about how it modifies the neuronal metabolism and excitability in order to reduce the seizure frequency. Possibly, the real mechanism of reduction of cortical hyperexcitability involves multiple factors. Some of the systems involved in seizure reduction are related to metabolic changes in the blood and cerebrospinal fluid (CSF), including a decrease in glucose levels and an increase in KB. The mitochondria function and energy reserve may also play a role in the KD mechanisms, resulting in synapse stabilization and excitatory decrease.
The biggest shifts in your daily habits will be how you food shop and how you cook, and recipes that are ketogenic need to be followed rather than just low-carb. You will require the healthy fats in order to get into ketosis and have enough energy without the carbs. And you will be considerably more energetic and healthier when cooking your own keto-friendly food rather than buying supposedly keto foods off the shelf.
Now that we have discussed the role of the primary cholesterol molecules, you should have a better understanding of how they work together. Having high LDL isn’t necessarily bad, given that you have adequate HDL to help clear it from the blood stream and that you are not dealing with chronic inflammation. It is also important to have large particle LDL (pattern A) rather than small particle LDL (pattern B).
If I were you I wouldn’t worry about that. I would just be glad that the word is getting out on combatting cancer. The rewards of spreading good helpful lifechanging knowledge are far greater than anything money can buy. Problems have always followed the attitude of profiteering vs benefitting all who need help. Pay it forward, pass it on, and Live!
Chapter 6 continues with advice on customizing the diet, foods that are allowed or disallowed, meal preparation, and how to follow the diet when away from home, such as restaurant or travel dining. Chapter 7 presents a number of diverse topics of great practical importance especially to a cancer patient but seldom mentioned in popular diet books: alcohol consumption: how to handle incidental illnesses; sick days and menstrual cycles; stress; exercise; acidity and alkalinity; and vegetarianism. Finally there are 12 appendices that provide convenient worksheets and a wealth of advice and information that will save many telephone calls, and trips to the library or internet.
7. Raygan, F., Bahmani, F., Kouchaki, E., Aghadavod, E., Sharifi, S., Akbari, E., . . . Asemi, Z. (2016). Comparative effects of carbohydrate versus fat restriction on metabolic profiles, biomarkers of inflammation and oxidative stress in overweight patients with Type 2 diabetic and coronary heart disease: A randomized clinical trial. PMID: 28607566
Health Impact News has published many articles about the low-carb high-fat ketogenic diet, and its favorable influences on several diseases or dysfunctional health conditions. The ketogenic diet was originally developed at Johns Hopkins Hospital in the 1920s to stop seizures in children with epilepsy, when pharmaceutical drugs did not work. More recently, the ketogenic diet has been used successfully for neurological disorders such as Alzheimer's disease. Recently, there have been efforts by some researchers and medical practitioners to explore the potential of ameliorating schizophrenia, a major brain disorder that affects one out of a hundred, with the aid of the ketogenic diet.
Jimmy Moore: This is where the fat, fat, fat comes in. That’s why I add butter and add coconut oil and the full fat dairy, and all the things that you can add fat to your diet and it makes it taste good. That’s the thing, people are like “Well, it’s not supposed to taste good, I’m on a diet.” I’m like “no, you’re on a live-it. Please live it up and have the fat.”
Cancer – One exciting frontier for the potential use of a ketogenic diet is as an adjunct treatment for certain types of cancers. In 1924 Otto Warburg first published his observation that, unlike healthy cells, nearly all cancer cells fuel themselves through glycolysis, a means of creating energy through the fermentation of glucose. What we now call the “Warburg Effect” has led many researchers to theorize that if cancer cells are starved of glucose, they will stop spreading, while healthy cells will continue to thrive on the alternative fuel source of ketones. In mice, a ketogenic diet is known to inhibit certain pathways and lower certain compounds involved in tumor formation.35 Research thus far is very preliminary, but because a ketogenic diet appears to target major energy pathways responsible for tumor growth and survival, it may enhance the efficacy of conventional treatments and even reduce side effects in some types of cancers. 36 37 38
Weight loss was also irresistible. I actually tried not to lose weight. Based on advanced bro science, I was supposed to maintain my weight if I ate at least 2,000 calories a day. Yet my efforts to stuff myself with gloriously fatty food were futile. I lost 10 kilos and got abs — “blurry” ones though. You still need a bit of imagination to count six.