It is an oversimplification that cancer cells use anaerobic fermentation all the time. Tumors have hypoxic zones and normoxic (aerobic) zones, with a symbiotic relationship between the two. Hypoxic cancer cells derive energy from fermentation of glucose, and secrete lactate. Normoxic cancer cells prefer and attract lactate as fuel for the TCA cycle, sparing glucose for the hypoxic cells. Cancer cells can switch fairly quickly between hypoxic and normoxic states, and may oscillate between the two. [NCBI, “Tumor cell metabolism: an integral view”]

You want to keep your cheats to none. Be prepared, make sure you’re eating what you need to be satiated (“full”), and make sure you’re satisfied with what you’re eating. If you have to force yourself to eat something, it will never work out in the end. This is just a guideline on how you can eat on a ketogenic diet, so you’re very welcome to change up what kind of foods you eat!

Sign up 24 hours before the general public and increase your chances of getting a spot. We only open the certification program twice per year. Due to high demand, spots in the program are limited and have historically sold out in a matter of hours. But when you sign up for the presale list, we’ll give you the opportunity to register a full 24 hours before anyone else.


When I was six years old, I was diagnosed with temporal lobe, partial-complex epilepsy.  Over the years, I have seen multiple doctors and neurologists and I have been on every medication created to treat epilepsy, but I still continued to have seizures about every 6-8 weeks. For the most part, I have been able to lead a normal life achieving my college degree, getting married and having two happy, healthy kids but every time I had a seizure it was a cruel reminder that I was not everything I needed to be for my family. Many times after a seizure, I would be unable to work and care for them for days at a time.

The American Academy of Neurology and the Child Neurology Society recommend adrenocorticotropic hormone (ACTH) as the first line of therapy for infantile spasms. The goals for this medication are to completely stop the infantile spasms and improve the abnormal EEG. In some cases, pediatric neurologists prescribe the seizure medication Sabril® (vigabatrin), especially for patients with tuberous sclerosis. Both drugs work well, but your child's doctor will talk with you about which medicine may be the better choice for your child.


For breakfast, we are going to change it up a bit. Here’s where we introduce ketoproof coffee. Now, don’t get me wrong – I know some of you won’t like it. If you’re not a fan of coffee, then try it with tea. If you’re not a fan of the taste (which is very rare), then try making a mixture of the ingredients by themselves and eating it like that. So, why ketoproof coffee?
In adults, the type of ketogenic diet typically used is the modified Atkins diet. Carbohydrates are limited to 20 grams per day and the intake of foods containing fat is required to get into the state of ketosis. For example, foods such as heavy cream, oils, avocado, eggs, butter and meats are encouraged; whereas conventional breads, pastas, cereals and cakes are restricted.

The most common side effects are constipation that can be supported with some dietary adjustments and laxatives. Other side effects that may occur that are relatively minor and transient include: kidney stones, low sugars, nausea, vomiting, diarrhea, sleepiness. There are some reports of longer term side effects that may include higher cholesterol, reduced bone health, kidney stones, slower linear growth velocity and abnormal heart rhythm.
David Book graduated with a PharmD from Drake University. After completing a Drug Information Residency in the greater Atlanta area with Mercer University's College of Pharmacy and InpharmD, he now works full time at an independent pharmacy. Drawn towards innovation and entrepreneurship, his interests include the business of pharmacy, healthcare advocacy, diet & nutrition, and health information technology.
It’s not as though Dr. Seyfried doesn’t cite clinical evidence. It’s just that the evidence is so darned thin and unconvincing thus far. For instance, in this talk, the first study he presents is a very small case series (two patients, actually) performed in 1995 in which two girls with inoperable astrocytomas were placed on a ketogenic diet in order to “determine if a ketogenic state would decrease glucose availability to certain tumors, thereby potentially impairing tumor metabolism without adversely affecting the patient’s overall nutritional status.” Interestingly (to me, at least) these case reports came from University Hospitals of Cleveland, where I did my general surgery residency. In fact, I was still there in 1995. Unfortunately, I don’t have access to the journal back to 1995; so I’m stuck with just the abstract. However, the abstract is pretty clear:
Like any trendy diet worth its balanced portion of salt, the keto diet is said to hold transformative powers. Proponents say it can help people lose weight, improve mood and experience fewer epileptic seizures. For the most part, the science seems to back these claims up — though, to be sure, it's not completely understood how exactly the keto diet affects mood (particularly depression), despite anecdotal evidence the diet might lead to clearer thinking and fewer symptoms of depression.
As you might suspect, this metabolic theory of cancers is controversial in the mainstream cancer paradigm, but there’s already promising initial evidence to support it, and most traditional cancer specialists concede that this metabolic theory has merit, and it may be a piece of the puzzle. I would say that the dominant paradigm idea right now is that metabolic dysfunction is likely one of the pieces of the puzzle, but that cancer is multifactorial and probably does involve genetic mutations that may be independent of metabolic dysfunction and that there are other causes that may not be directly related to metabolic dysfunction.
But there is evidence that low-carb diets may increase metabolism, according to a paper published November 14 in BMJ. Researchers found that overweight adults who lowered carbohydrates and added more fat into their diets burned about 250 calories more each day than people on high-carb, low-fat diets. The study is impressive because it's the largest, most expensive, and controlled study of its kind.
When a person first starts onto a low-carbohydrate ketogenic diet, it takes the body several days to a few weeks to shift from relying on glucose to instead rely on fat. During this transition, people may experience what is sometimes referred to as the “keto-flu”—muscle cramps, headaches, fatigue, dizziness, nausea, and sugar and carbohydrate cravings.49 There may also be increased urination which can result in a loss of minerals, such as sodium and potassium. To counter these effects one should strive to get more minerals and in particular, more sodium and potassium, drink plenty of water, get some exercise and ensure adequate caloric intake. Once the body becomes keto-adapted, these symptoms largely resolve, and many people report increased energy, decreased cravings and weight loss.
In fact, ketogenic diets have been used for nearly a century to treat seizures, says Gary Yellen, a professor or neurobiology at Harvard Medical School. “It dates back to studies from the 1920s that found this kind of diet was like a sustainable form of fasting, which we’ve known, supposedly since antiquity, to be beneficial for epilepsy,” he says.
Today, you’ll see ketogenic diets promoted to prevent disease, increase energy, boost physical and mental performance, and so much more. But let’s face it: Most people want to try keto to lose weight. While that’s not a bad thing—you can lose weight doing it—ketogenic diets were never designed for weight loss, and done incorrectly, a side effect can actually make you gain weight.
The failure of Big Pharma to develop an Alzheimer's drug has been well-documented in the corporate-sponsored "mainstream" media. As Alzheimer's diagnoses continue to increase, drug companies are scrambling to develop the next big drug to market to seniors. In modern times, the most successful drugs in sales, so far, have been cholesterol-lowering statin drugs, as one out of every five people over the age of 50 are now taking drugs to lower one's cholesterol, raking in billions of dollars for pharmaceutical companies. The sick irony to this is that lowering one's cholesterol artificially is directly linked to declining cognitive health and diseases such as Alzheimer's, since 25% of one's total cholesterol is located in the brain. The failed scientific hypothesis behind these drugs is that cholesterol is a cause of heart disease, and that diets high in saturated fats contribute to high cholesterol. However, the actual science shows almost the opposite, and when one looks at death rates, for example, lower cholesterol rates do not equate to longer life - in fact the converse is true: higher cholesterol levels lead to longer life spans. The pharmaceutical industry and the U.S. government cannot afford to reverse their warnings against saturated fats and cholesterol, however, as it would be the same as confessing that the entire statin drug industry has been a scam, and that statin drugs actually cause more harm than good. This is the main reason why the USDA must continue supporting a low-fat diet and condemning saturated fats, even though the science does not support their positions. It is no surprise, therefore, to learn that peer-reviewed scientific studies continue to show that the high-fat ketogenic diet supports cognitive health and can help prevent or reduce cognitive diseases such as Alzheimer's. Here are four new studies just published on the high-fat ketogenic diet related to cognitive health, and preventing Alzheimer's Disease.

One of my favorite patients, whom I have discussed at times in my lectures, was diagnosed in August 1991 with stage IV pancreatic cancer, with multiple metastases into the liver, into the lung, into both adrenals, and into the bone. After a lung biopsy confirmed adenocarcinoma, his doctors discouraged chemotherapy, telling him and his wife conventional treatments would only ruin his quality of life while offering no benefit.
Variations on the Johns Hopkins protocol are common. The initiation can be performed using outpatient clinics rather than requiring a stay in hospital. Often, no initial fast is used (fasting increases the risk of acidosis, hypoglycaemia, and weight loss). Rather than increasing meal sizes over the three-day initiation, some institutions maintain meal size, but alter the ketogenic ratio from 2:1 to 4:1.[9]
Essentially, the keto diet for beginners works by “tricking” the body into acting as if its fasting (while reaping intermittent fasting benefits), through a strict elimination of glucose that is found in carbohydrate foods. Today the standard keto diet goes by several different names, including the “low-carbohydrate” or “very-low-carbohydrate ketogenic diet”(LCKD or VLCKD for short).

25-30 grams a day is about my max with carbs, which my avocado … when I have avocado, that’s about half of that allotment. I have to be real careful with that. My protein is about 80-100 grams. Doesn’t sound like a lot, I’m 6 foot 3, I’m doing my standing work desk here … 6 foot three in a big guy, 80-100 grams doesn’t sound like a lot but if I go over that I start having that gluconeogenesis kick in, and I can see it on my blood sugar monitor and I can see it on my blood ketone monitor. They go in the wrong direction. You have to be real mindful. Then you’re like, okay you cut the carbs, you moderate the protein, well then what do you eat? Hmm.
Jimmy Moore: Yeah. The next book that I’m going to write with my co-author, Dr. Eric Westman, not anytime soon because I’m tired of writing books right now … when we get back to it, it’s going to be on this blood sugar topic because it is one that is so confusing to people and I think focusing so intently on blood sugar is the wrong question to ask. I think we should be looking at blood insulin. I think that will be the tell tale sign of what’s really going on in your body. Blood sugar is going to do what it’s going to do. The body is trying, especially if you’re insulin resistant which a lot of people coming into a low carb, high fat diet are, hello …
If you lift weights on a ketogenic diet, you might fear losing muscle mass taking in lower amounts of protein. That doesn’t seem to be the case since your body preferentially utilizes fat rather than protein during ketosis. Growth hormone, an anabolic hormone sometimes called your fountain-of-youth hormone because it keeps you lean and toned, plays a major role in regulating muscle growth and development, stimulating muscle protein synthesis. Researchers find a very-low carbohydrate diet with sufficient protein does not affect growth hormone levels, at least in the short-term. If you’re a regular lifter, you might want to consider slightly increasing your protein intake during workout days and supplementing with a branched-chain amino acid (BCAA) supplement. Cyclical keto, where you would eat a higher-carbohydrate diet during your workout days, also makes for a smart strategy to maintain muscle.
So, what evidence does Dr. Seyfried himself provide to prove his point that the best diet for all cancer patients, whatever the type, is the ketogenic, high fat, no carb diet? Well, very little. Certainly the 400 plus pages of elaborate biochemistry and theory are impressive and informative. But in terms of practicalities, that is, results with actual human patients diagnosed with cancer, there is next to no evidence.
Nonetheless, enthusiastic oncologists joined with the media, portraying insurance companies as heartless, greedy bullies depriving women with breast cancer of a curative treatment. Not too long after, the trial lawyers got involved, orchestrating a series of lawsuits against various insurance companies on behalf of women wanting a BMT. In a particularly notable and telling case, Fox vs. HealthNet, the jury awarded the plaintiff, a woman diagnosed with breast cancer whose insurance carrier refused to cover the procedure, $89 million, including $77 million in punitive damages.
The American Academy of Neurology and the Child Neurology Society recommend adrenocorticotropic hormone (ACTH) as the first line of therapy for infantile spasms. The goals for this medication are to completely stop the infantile spasms and improve the abnormal EEG. In some cases, pediatric neurologists prescribe the seizure medication Sabril® (vigabatrin), especially for patients with tuberous sclerosis. Both drugs work well, but your child's doctor will talk with you about which medicine may be the better choice for your child.
Familial hypercholesterolemia (FH) is a condition characterized by extremely elevated total and LDL cholesterol levels, strong family history of heart disease, and fatty deposits under the skin, including the eyelids. People with FH are at very high risk of heart attack. It's a fairly common condition currently estimated to affect one out of every 150 people (8).
As I wrote in my book, “Nevertheless on the therapy [Kelley’s] he slowly began to improve, to the point his mental status normalized and over a period of a year, he progressed from a wheelchair to a walker to a cane.” When I completed my study in 1987, he had survived 5 years and was in excellent health, with no evidence of cancer in his brain or spinal canal.
There are some treatment centers like Care Oncology Clinic in the UK and ChemoThermia Oncology Center in Istanbul that are using ketogenic diet and fasting along with glucose inhibitors and conventional treatment like chemo. They claim to be getting good results, but I don’t know much about these cancer centers above and beyond what I just told you. Note that keto only seems to work with the faster-growing cancers like breast cancer, but not as much with slower-growing cancers like prostate cancer.
I also want to be clear that I’m not making any specific recommendation here for treatment of cancer using ketogenic diet or anything else. As I’ve argued earlier in the podcast, I think cancer is a complex multifactorial disease and varies from individual. The ideology and pathology vary from individual to individual, and treatment decisions should be made with the support of an oncologist and other doctors on the care team. Please don’t take anything that I’ve said in this podcast as a recommendation for your particular situation or somebody in your life that’s struggling with cancer.

I also want to be clear that I’m not making any specific recommendation here for treatment of cancer using ketogenic diet or anything else. As I’ve argued earlier in the podcast, I think cancer is a complex multifactorial disease and varies from individual. The ideology and pathology vary from individual to individual, and treatment decisions should be made with the support of an oncologist and other doctors on the care team. Please don’t take anything that I’ve said in this podcast as a recommendation for your particular situation or somebody in your life that’s struggling with cancer.

High-protein ketogenic diet (HPKD): This version of the keto diet is often followed by folks who want to preserve their muscle mass like bodybuilders and older people. Rather than protein making up 20 percent of the diet, here it’s 30 percent. Meanwhile, fat goes down to 65 percent of the diet and carbs stay at 5 percent. (Caution: folks with kidney issues shouldn’t up their protein too much.)
The ketogenic diet is a natural, nontoxic metabolic therapy being studied and utilized for cancer prevention and treatment. It works because cancer cells are dependent upon a constant supply of blood sugar (glucose) to stay alive. Normal cells can make energy from both glucose and ketones (metabolic by-products of burning fat), but most cancer cells can only use glucose. Avoiding carbohydrates (starch and sugar) while enjoying delicious and healthy protein and fats will lower blood glucose and increase blood-ketone levels, resulting in a normal body state called nutritional ketosis. Research has shown that nutritional ketosis starves cancer cells while nourishing normal cells and strengthening total body health.
Jimmy Moore: Let’s look at all of those things. Let’s look at the triglycerides, let’s look at the HDL, let’s look at the HSCRP, let’s see how your blood sugar is doing, your fasting insulin levels are doing. All of it matters and I think anybody that tries to do treatment of their high cholesterol, which is not a disease by the way, they might even call it hypercholesterolemia, to make it sound like it’s just this dastardly thing. It’s just a medical term that says you have high cholesterol.

As you might suspect, this metabolic theory of cancers is controversial in the mainstream cancer paradigm, but there’s already promising initial evidence to support it, and most traditional cancer specialists concede that this metabolic theory has merit, and it may be a piece of the puzzle. I would say that the dominant paradigm idea right now is that metabolic dysfunction is likely one of the pieces of the puzzle, but that cancer is multifactorial and probably does involve genetic mutations that may be independent of metabolic dysfunction and that there are other causes that may not be directly related to metabolic dysfunction.
This week we’re introducing a slight fast. We’re going to get full on fats in the morning and fast all the way until dinner time. Not only are there a myriad of health benefits to this, it’s also easier on our eating schedule (and cooking schedule). I suggest eating (rather, drinking) your breakfast at 7am and then eating dinner at 7pm. Keeping 12 hours between your 2 meals. This will help put your body into a fasted state.
Patients on the KD should be seen regularly every 3 months, and the family should be able to easily contact the diet team to resolve possible doubts and discuss adverse effects. In each evaluation, the seizure dairy and the child’s cognitive development and behavior should be observed (Auvin and Nabbout, 2011). It has been noted that it is possible to improve the cognitive development and behavior even without a change in the seizure frequency. Although some authors have reported no relationship between the efficacy and the level of ketosis, it is still recommended to measure the urine ketosis several times a week (Kossoff et al., 2009).
Sign up 24 hours before the general public and increase your chances of getting a spot. We only open the certification program twice per year. Due to high demand, spots in the program are limited and have historically sold out in a matter of hours. But when you sign up for the presale list, we’ll give you the opportunity to register a full 24 hours before anyone else.
A recent study found that ketone supplementation extended survival in mice with metastatic cancer. But while it’s true that most cancers have a highly anaerobic metabolism, this in not universal. If proven to be effective, it’s likely that ketone supplementation would be an additional treatment rather than a stand alone treatment for cancer, because of its robust nature.
The initial pronouncements, released with such glowing enthusiasm, indicated that finally, yes finally, after so many disappointments we might actually be looking at a real, universal cancer cure. In both laboratory and preliminary human trials, interleukin-2 – like interferon before it, a natural product secreted by lymphocytes that stimulates other cancer-fighting immune cells into action – had performed almost magically against even the most aggressive of cancers, such as metastatic melanoma and metastatic kidney cancer.

Dr. Luis Caicedo, a pediatric gastroenterologist and director of the Fecal Microbiota Transplant Program at Nicklaus Children's Hospital in Miami, who was not involved in the study, called the research "very exciting." It "opens the door for more investigations… and certainly gives you more data on why this ketogenic diet works so [well]" for epilepsy, Caicedo said.
Look, the good doctor is right – he only forgot to stress “portion control” which is why many fanatical dieters are so kee-jerk reactive to any discussion – odds are you over ate like a hog before your keto diet, and are weak and insecure in your diet plans. Eat EVERYTHING in small amounts, and you will live long and prosper. The only thing to avoid are processed foods. Cook your meals from scratch using quality ingredients.
At the time I finished my monograph in 1986, I hoped that with its publication, fair-minded researchers might begin taking Dr. Kelley and his nutritional therapy seriously. As I was to learn, I completely and rather naively misjudged the animus of the scientific community toward unconventional cancer treatment approaches that didn’t fit the “accepted” model. Even with Dr. Good’s support, after two years of trying I could not get the book published, either in its entirety, or in the form of individual case reports appropriate for the conventional medical journals.
They’re totally ignoring HDL. They’ll say, “Oh yeah, it looks good. But oh my god your LDL is bad or your total cholesterol is bad.” The other thing that they’re ignoring about your cholesterol panel which doesn’t necessarily show up in your numbers that they look at is the triglycerides. If you’ve got your numbers and you’re looking at them now, go grab them and let’s look at them. If you have a triglyceride number over 100, I know they say the range is 150 or below but over 100 means you’re eating way too many carbohydrates in your diet still. The tell tale sign that you’re eating low carb, high fat, keto very well is your triglycerides will be sub 100 and then sub 70 optimally.

Despite continuous advances in the medical world, obesity continues to remain a major worldwide health hazard with adult mortality as high as 2.8 million per year. The majority of chronic diseases like diabetes, hypertension, and heart disease are largely related to obesity which is usually a product of unhealthy lifestyle and poor dietary habits. Appropriately tailored diet regimens for weight reduction can help manage the obesity epidemic to some extent. One diet regimen that has proven to be very effective for rapid weight loss is a very-low-carbohydrate and high-fat ketogenic diet.[1][2][3]

A popular keto supplement are exogenous ketones (popularly called “keto diet pills”) that may help you achieve results earlier as well as remain in that state. (Don’t confuse exogenous ketones with raspberry ketones, as the latter don’t raise ketone levels in the body or mimic endogenous ketones, so you wouldn’t use raspberry ketones in your regimen.)
Then you’ve got "keto-approved" junk foods like cookies, candy, and bread that promise to keep you in ketosis even as you indulge in your favorite comfort foods. The flip side is ketogenic diets that include almost no plant foods, focusing instead on meat, meat, and more meat. Bring on the bacon. Slather your steak in butter. Who needs vegetables? (Hint: You do!) Ketogenic diets are a practical invitation for vegetable-phobic people, and when you skip out on gut-healing plant foods, you create microbiome mayhem.
I’ve been Keto for over a year now. I’ve lost 60 lbs. I’m off Metformin for type 2 diabetic and my LDL has improved significantly. In my experience, Keto will show some quick results in some but for others it will take longer. It depends on how long you’ve been on the standard American diet. It will take time for your body to fix “self-heal”. Not everyone will have the same results in the same amount of time.
When a person first starts onto a low-carbohydrate ketogenic diet, it takes the body several days to a few weeks to shift from relying on glucose to instead rely on fat. During this transition, people may experience what is sometimes referred to as the “keto-flu”—muscle cramps, headaches, fatigue, dizziness, nausea, and sugar and carbohydrate cravings.49 There may also be increased urination which can result in a loss of minerals, such as sodium and potassium. To counter these effects one should strive to get more minerals and in particular, more sodium and potassium, drink plenty of water, get some exercise and ensure adequate caloric intake. Once the body becomes keto-adapted, these symptoms largely resolve, and many people report increased energy, decreased cravings and weight loss.
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