HDL cholesterol transfers the extra cholesterol from the blood to the liver for removal from the body and is also referred to as “good” cholesterol. LDL cholesterol transfers the cholesterol within the bloodstream to the parts of the body where cell repair is needed and also inside the arteries. It is also known as “bad” cholesterol. Total cholesterol is HDL and LDL cholesterol combined (4).
My Husband and I started doing Keto July 2018. We got over weight after we got out of the Marine Corps. It has been hard to workout because I became disabled, but my diet was not good. After our friend Amber recommended your site and support group, we found a lot of helpful information to get us started on a successful journey. So far it’s been one month and we have lost 18 pounds each!
Studies assessing the efficacy of the MAD reported seizure freedom rates of up to 25% and seizure reduction rates of up to 60% in children. One study used a simplified MAD (sMAD) and reported seizure freedom rates of 15% and seizure reduction rates of 56% in children. One study utilised a MAD in adults and reported seizure reduction rates of 35%, but no patients became seizure free (GRADE rating low).
In other words, clinical data should be rolling in fairly soon, and that’s a good thing. In the meantime Dr. Seyfried and other advocates who so passionately believe that ketogenic diets will greatly help patients with brain cancer do no one any favors by claiming unequivocally that cancer is a metabolic disease and saying that ketogenic diets are more beneficial than chemotherapy for patients with brain tumors.
It’s understandable that you may be wondering how to sort out the facts and interpret the latest research. Who is a good candidate for keto, and who should avoid it? How does someone successfully adhere to a ketogenic diet? In this article, I’ll answer these important questions and others so you can make an educated decision about whether keto is right for you.
You have to keep the protein under control, it can get out of control and people then wonder “Well I’m eating next to no carbs, why am I so hungry? Why is my blood sugar all whack-a-doodle? I thought this Leanne lady with the glasses on YouTube said it wasn’t going to be that way?” Unfortunately, you need to pay attention to the protein as well. Just to give you an example of how mine looks, I can have about 25-30 grams of carbohydrates. I often joke Leanne that I’ve had all the carbs I’m allowed to have my entire life, the first 32 years of my life. Okay, it may not be true but it’s probably closer to true than not, that I have to limit them the rest of my life.
One of the primary culprits of chronic inflammation in our society is a poor diet full of sugars and processed vegetable oils. In fact, blood sugar and measurements of insulin resistance are a much more accurate predictor of heart disease risk. I often look at values such as fasting glucose, HbA1c, and fasting insulin as a means of determining the inflammatory state of someone’s body.

Jimmy Moore: Yeah. The next book that I’m going to write with my co-author, Dr. Eric Westman, not anytime soon because I’m tired of writing books right now … when we get back to it, it’s going to be on this blood sugar topic because it is one that is so confusing to people and I think focusing so intently on blood sugar is the wrong question to ask. I think we should be looking at blood insulin. I think that will be the tell tale sign of what’s really going on in your body. Blood sugar is going to do what it’s going to do. The body is trying, especially if you’re insulin resistant which a lot of people coming into a low carb, high fat diet are, hello …
I would receive further support for my thinking during the summer of 1981, after completing my second year of medical school. That July, through one of my journalism contacts from my previous life, I had the opportunity to meet the controversial alternative cancer practitioner, the dentist Dr. William Donald Kelley. Over a 20 year period beginning in the early 1960s, Kelley had developed a very intensive nutritional approach to cancer that came under harsh public scrutiny and media attention when he agreed to treat Steve McQueen.
With this rationale, VanItallie et al. [39, Class III] performed a feasibility study with PD patients and the ketogenic diet. They explored whether PD patients would be able to prepare the ketogenic diet in their homes and remain on it for at least 1 month. Of seven patients enrolled, five completed the study. They were monitored for ketone levels and weekly Unified Parkinson Disease Rating Scale (UPDRS) scores. All the patients lost weight. Interestingly, the mean decrease in UPDRS scores was 43.4%. A placebo effect is not ruled out, but this result at least suggests that the ketogenic diet was not harmful and certainly invites further study into its role in preserving neuron function in PD and other neurodegenerative diseases. The possibility that the diet may have altered levodopa absorption (and that this factor, rather than an effect of the diet on neuronal function, was responsible for the change) has not been studied rigorously [40].
They’re totally ignoring HDL. They’ll say, “Oh yeah, it looks good. But oh my god your LDL is bad or your total cholesterol is bad.” The other thing that they’re ignoring about your cholesterol panel which doesn’t necessarily show up in your numbers that they look at is the triglycerides. If you’ve got your numbers and you’re looking at them now, go grab them and let’s look at them. If you have a triglyceride number over 100, I know they say the range is 150 or below but over 100 means you’re eating way too many carbohydrates in your diet still. The tell tale sign that you’re eating low carb, high fat, keto very well is your triglycerides will be sub 100 and then sub 70 optimally.
So sugar feeds the cancer cells- you dont have to go full keto just stop eating sugar? I keep reading meat causes cancer and a vegan diet is best! When you cut out sugar and all grains you end up eating dairy and meat, with nuts for a treat. Friut is off the list, honey and some root veg like potatos so if you cut down on meat what the feck are we left with? you can only eat so many eggs,avocados and spinach. I also am yet to find a keto dessert I like, coconut flour and stevia dosent make a cake.
In children who can be successfully withdrawn from anti-convulsant therapy and are seizure-free for 2 years on the ketogenic diet (about 10 percent of treated children), an EEG is repeated and the ketogenic diet is slowly withdrawn. However, the diet is often stopped earlier if not successful. Similarly, after 2 years in children with continued seizures, most ketogenic diet centers will at least try to have the children come off the diet and see if it is no longer necessary for control.

Make things yourself. While it’s extremely convenient to buy most things pre-made or pre-cooked, it always adds to the price per pound on items. Try prepping veggies ahead of time instead of buying pre-cut ones. Try making your stew meat from a chuck roast. Or, simply try to make your mayo and salad dressings at home. The simplest of things can work to cut down on your overall grocery shopping.

A study with an intent-to-treat prospective design was published in 1998 by a team from the Johns Hopkins Hospital[20] and followed-up by a report published in 2001.[21] As with most studies of the ketogenic diet, no control group (patients who did not receive the treatment) was used. The study enrolled 150 children. After three months, 83% of them were still on the diet, 26% had experienced a good reduction in seizures, 31% had had an excellent reduction, and 3% were seizure-free.[Note 7] At 12 months, 55% were still on the diet, 23% had a good response, 20% had an excellent response, and 7% were seizure-free. Those who had discontinued the diet by this stage did so because it was ineffective, too restrictive, or due to illness, and most of those who remained were benefiting from it. The percentage of those still on the diet at two, three, and four years was 39%, 20%, and 12%, respectively. During this period, the most common reason for discontinuing the diet was because the children had become seizure-free or significantly better. At four years, 16% of the original 150 children had a good reduction in seizure frequency, 14% had an excellent reduction, and 13% were seizure-free, though these figures include many who were no longer on the diet. Those remaining on the diet after this duration were typically not seizure-free, but had had an excellent response.[21][22]
Perhaps the first person to really put ketogenic diets on the map was Dr. Robert C. Atkins, a cantankerous medical doctor who began experimenting with a low-carb diet in 1963. His first book, Dr. Atkins Diet Revolution, was published in 1972. Dr. Atkins died in 2003 from a tragic fall (interestingly, the Atkins website’s timeline does not mention his death), but his diet plan lives on today.
What was formerly only qualitative has now become quantitative. What was formerly only probable has now become certain. The era in which the fermentation of the cancer cells or its importance could be disputed is over, and no one today can doubt that we understand the origin of cancer cells if we know how their large fermentation originates, or, to express it more fully, if we know how the damaged respiration and the excessive fermentation of the cancer cells originate.”
In terms of our specific discussion, diet as cancer treatment, Dr. Kelley demonstrated more recently in his Dallas, Texas, and Winthrop, Washington offices, no one diet suits all patients diagnosed with the disease, quite the contrary. Over a 20 year period working in the trenches treating many thousands of people, Dr. Kelley came to learn that each patient who walked into his office required a diet designed specifically for his or her metabolic needs, and these dietary requirements could vary enormously from patient to patient.
A: The amount of weight you lose is entirely dependent on you. Obviously adding exercise to your regimen will speed up your weight loss. Cutting out things that are common “stall” causes is also a good thing. Artificial sweeteners, dairy, wheat products and by-products (wheat gluten, wheat flours, and anything with an identifiable wheat product in it).
The ketogenic diet is a mainstream dietary therapy that was developed to reproduce the success and remove the limitations of the non-mainstream use of fasting to treat epilepsy.[Note 2] Although popular in the 1920s and '30s, it was largely abandoned in favour of new anticonvulsant drugs.[1] Most individuals with epilepsy can successfully control their seizures with medication. However, 20–30% fail to achieve such control despite trying a number of different drugs.[9] For this group, and for children in particular, the diet has once again found a role in epilepsy management.[1][10]
The ketogenic diet has been shown to produce beneficial metabolic changes in the short-term. Along with weight loss, health parameters associated with carrying excess weight have improved, such as insulin resistance, high blood pressure, and elevated cholesterol and triglycerides. [2,7] There is also growing interest in the use of low-carbohydrate diets, including the ketogenic diet, for type 2 diabetes. Several theories exist as to why the ketogenic diet promotes weight loss, though they have not been consistently shown in research: [2,8,9]
Recent animal studies suggest a role for the ketogenic diet as a potential therapy for amyotrophic lateral sclerosis (ALS). ALS results from the death of motor neurons in the brain and spinal cord. A small number of cases are caused by an inherited mutation in the gene encoding the Cu/Zn superoxide dismutase I (SOD1). Mice expressing the mutated gene recapitulate the progressive muscle weakness and death due to respiratory failure seen in humans with ALS. Various lines of evidence suggest that mitochondrial dysfunction may play a role in the pathogenesis of ALS. A recent study suggests that ketosis induced by the ketogenic diet might affect progression of the disease [47]. Transgenic SOD1 mice fed a high-fat diet (60% of calories from fat, compared with < 10% fat in standard rodent chow and > 90% of calories from fat in a typical rodent ketogenic diet) preserved their performance on a standard rotorod test longer than those fed a regular diet. Mice were fed ad lib, and mice fed the high-fat diet gained more weight than those on the standard diet, so overall caloric restriction was unlikely to be a factor in this study. When spinal cords were examined, significantly more motor neurons were preserved in the mice fed the ketogenic diet than in those fed a regular diet. However, the ketogenic diet did not significantly prolong survival.
One notes that the patient who didn’t survive 12 months wasn’t much mentioned; so I assume she didn’t demonstrate any clinical improvement. In any case, this study doesn’t really show anything, other than that a ketogenic diet might decrease glucose uptake in some brain tumors. It’s like a Burzynski case report, in which we have no idea whether the patient did better than expected because of the intervention or because she had less aggressive disease.
In my opinion, Bob Atkins knew more about the theory and practice of the ketogenic diet, its benefits and limitations, including as applied to cancer patients, than anyone in the history of medicine. For him, the concept was hardly the musings of a PhD laboratory scientist, but the practical observations of a physician who treated thousands of patients over decades. And for cancer, the ketogenic diet just did not seem to work.
The KetoPet Sanctuary was started in 2014 to rescue shelter dogs with terminal cancer and give them a forever home. Once at KetoPet, each dog was placed on a raw ketogenic diet (high fat, adequate protein, very low carbohydrates). We then did something that was never done before: we used PET (positron emission tomography) to image disease and validate our nutrition-first approach. While not a cure, we found a raw ketogenic diet to be effective in improving outcomes for dogs with cancer. Even more, these case studies support our belief that all dogs should eat a raw ketogenic diet optimal health.
Jimmy Moore: Just removing the infections that were in the mouth and the mercury amalgam poisoning that was probably happening. Was raising my cholesterol because it was trying to be that fire fighter to put out the fire. Of course it never showed up in my inflammation because the cholesterol was taking care of it, had I been taking a Staten drug Leanne, I would have been at great risk. I would have been in really bad shape. Anyway, I thought okay that was maybe an anomaly, that was in October. Let me have it run again, I had it run again last month … 289 again. Not a fluke, and that’s one of the things we did in Cholesterol Clarity, was you said, “why aren’t doctors asking why the cholesterol is high?” All they know is that it’s high. Therefore you have a Staten deficiency and please take this drug.
There is not one “standard” ketogenic diet with a specific ratio of macronutrients (carbohydrates, protein, fat). The ketogenic diet typically reduces total carbohydrate intake to less than 50 grams a day—less than the amount found in a medium plain bagel—and can be as low as 20 grams a day. Generally, popular ketogenic resources suggest an average of 70-80% fat from total daily calories, 5-10% carbohydrate, and 10-20% protein. For a 2000-calorie diet, this translates to about 165 grams fat, 40 grams carbohydrate, and 75 grams protein. The protein amount on the ketogenic diet is kept moderate in comparison with other low-carb high-protein diets, because eating too much protein can prevent ketosis. The amino acids in protein can be converted to glucose, so a ketogenic diet specifies enough protein to preserve lean body mass including muscle, but that will still cause ketosis.

The ketogenic diet is a natural, nontoxic metabolic therapy being studied and utilized for cancer prevention and treatment. It works because cancer cells are dependent upon a constant supply of blood sugar (glucose) to stay alive. Normal cells can make energy from both glucose and ketones (metabolic by-products of burning fat), but most cancer cells can only use glucose. Avoiding carbohydrates (starch and sugar) while enjoying delicious and healthy protein and fats will lower blood glucose and increase blood-ketone levels, resulting in a normal body state called nutritional ketosis. Research has shown that nutritional ketosis starves cancer cells while nourishing normal cells and strengthening total body health.
Discuss this treatment option with your neurologist. If your neurologist feels that the ketogenic diet is a possible option, then bloodwork tests and other investigations may be required to determine if the ketogenic diet can be safely implemented. You may then meet members of the ketogenic diet team such as a registered dietitian, nurse, nurse practitioner, social worker, child life specialist and pharmacist who may offer their assessment on how best to plan for the ketogenic diet. Please note that many centres may have a waiting list.
This is so important. I think people need to know just because you lower your LDL doesn’t mean you’ve necessarily made yourself healthier. What it does when you have the vegetable oils and you lower your LDLC, you could see your total cholesterol go to 150 for example. Okay, you think you’ve done something good, what you’ve done though is you totally eliminated all of those healthy pattern A, the large fluffy kind, you’ve totally eliminated those drinking these vegetable oils because you’ve oxidized the LDL, making them into more of those small LDL and you’re at great risk for heart disease.
Anticonvulsants suppress epileptic seizures, but they neither cure nor prevent the development of seizure susceptibility. The development of epilepsy (epileptogenesis) is a process that is poorly understood. A few anticonvulsants (valproate, levetiracetam and benzodiazepines) have shown antiepileptogenic properties in animal models of epileptogenesis. However, no anticonvulsant has ever achieved this in a clinical trial in humans. The ketogenic diet has been found to have antiepileptogenic properties in rats.[56]
Now a report, appearing several weeks ago in the journal Neurology, reveals that in fact, a ketogenic diet is also profoundly helpful in adults as well in terms of treating epilepsy. This research, published by investigators in Maryland, found that there was at least a 50% reduction in seizures in 32% of patients treated with a ketogenic diet as well as in 29% of patients who went on a modified Atkins diet. In fact, 9% of those placed on the ketogenic diet and 5% of those placed on the modified Atkins diet had a greater than 90% reduction in the frequency of their epileptic seizures. These diets were designed such that the bulk of calories, between 67% and 75%, came from fat. The study revealed that “the anticonvulsant effect occurs quickly with both diets, within days to weeks.” Interestingly, the most common side effect was weight-loss which the office indicated “maybe advantageous inpatients with obesity.”

If you’ve decided to move forward in trying the keto diet, you will want to stick to the parameters of the eating plan. Roughly 60 to 80 percent of your calories will come from fats. That means you’ll eat meats, fats, and oils, and a very limited amount of nonstarchy vegetables, she says. (This is different from a traditional low-carb diet, as even fewer carbs are allowed on the keto diet.)
Jimmy Moore: The good news is even the dietary guidelines committee is acknowledging “oops, we got it wrong when it came to dietary cholesterol.” A lot of people haven’t heard this yet, because they haven’t released the full report but they now have backed away from limiting the amount of cholesterol that you consume in your diet. You know how eggs have always been vilified because of there cholesterol content? They’re now saying, “Okay it’s not dietary cholesterol that’s the enemy. Please start eating cholesterol again.” You still go into stores and “Cholesterol free food.” It’s a natural cholesterol. I’m going “Okay, so something is going to have to happen.” It is happening Leanne.
• Weight loss — If you're trying to lose weight, then a ketogenic diet is one of the best ways to do it, because it helps access your body fat so that it can be shed. Obese people in particular can benefit from this method. In one study, obese test subjects were given a low-carb ketogenic diet and a low-fat diet. After 24 weeks, researchers noted that the low-carb group lost more weight (9.4 kilograms or 20.7 pounds) compared to the low-fat group (4.8 kilograms or 10.5 pounds).1
Similarly, in a 2015 study, mice receiving a combination of hyperbaric oxygen and dietary ketone supplementation showed a clear reduction in tumor growth rate and metastasis.20 Also, these mice lived twice as long as control animals. Based on these results, the study authors state that further investigation into the effectiveness of this combination therapy as a potential treatment for late-stage metastatic cancers is urgently required.
The take-home message here is that patients with epilepsy have options beyond simple pharmaceutical intervention, and these include dietary changes which well-respected science is now validating as having significant efficacy. A fundamental cornerstone of the Grain Brain Program is profound reduction of carbohydrates and sugars while increasing “good” dietary fats. This approach tends to favor a low grade of ketosis which may well be the normal state of human metabolism. I have written extensively both on the site and in Grain Brain how this dietary approach has profound health-related benefits that relates to weight loss, metabolism, energy, reduction of inflammation, and even reduce risk for diabetes and cancer. This new report offers up yet another benefit to a higher fat lower carbohydrate dietary approach, in this case, for a disease that is devastating for so many.
The most common side effect encountered is constipation. Many of the children who begin the diet are already prone to this problem because of limited mobility, hypotonia, or spasticity. Constipation can be treated with regular doses of polyethylene glycol, fiber, increased fluids, salt, mineral oil, intermittent pediatric-dose enemas, or magnesium hydroxide . Other more common side effects include hunger, acidosis (during illness), and hypoglycemia (just during the start of the diet). Many children as well can have gastroesophageal reflux, which can be managed with medications. The high fat content decreases gastric emptying, which promotes gastroesophageal reflux.
Wilder's colleague, paediatrician Mynie Gustav Peterman, later formulated the classic diet, with a ratio of one gram of protein per kilogram of body weight in children, 10–15 g of carbohydrate per day, and the remainder of calories from fat. Peterman's work in the 1920s established the techniques for induction and maintenance of the diet. Peterman documented positive effects (improved alertness, behaviour, and sleep) and adverse effects (nausea and vomiting due to excess ketosis). The diet proved to be very successful in children: Peterman reported in 1925 that 95% of 37 young patients had improved seizure control on the diet and 60% became seizure-free. By 1930, the diet had also been studied in 100 teenagers and adults. Clifford Joseph Barborka, Sr., also from the Mayo Clinic, reported that 56% of those older patients improved on the diet and 12% became seizure-free. Although the adult results are similar to modern studies of children, they did not compare as well to contemporary studies. Barborka concluded that adults were least likely to benefit from the diet, and the use of the ketogenic diet in adults was not studied again until 1999.[10][14]

For breakfast, we are going to change it up a bit. Here’s where we introduce ketoproof coffee. Now, don’t get me wrong – I know some of you won’t like it. If you’re not a fan of coffee, then try it with tea. If you’re not a fan of the taste (which is very rare), then try making a mixture of the ingredients by themselves and eating it like that. So, why ketoproof coffee?
Just wanted to share with you that I have been ordering oil for my sister-in-law who had a Glioblastoma Multiform Brain Tumour. After surgery, 6 weeks of radiotherapy and 3 months of chemo (plus your amazing M10P treatments), my sister-in-law is tumour free as of today! Thank you so much for the service you provide. Feel free to share this story with other members who need a boost and some good news! Thanks again
However, this diet is gaining considerable attention as a potential weight-loss strategy due to the low-carb diet craze, which started in the 1970s with the Atkins diet (a very low-carbohydrate, high-protein diet, which was a commercial success and popularized low-carb diets to a new level). Today, other low-carb diets including the Paleo, South Beach, and Dukan diets are all high in protein but moderate in fat. In contrast, the ketogenic diet is distinctive for its exceptionally high-fat content, typically 70% to 80%, though with only a moderate intake of protein.
Insulin is a hormone that lets your body use or store sugar as fuel. Ketogenic diets make you burn through this fuel quickly, so you don’t need to store it. This means your body needs -- and makes -- less insulin. Those lower levels may help protect you against some kinds of cancer or even slow the growth of cancer cells. More research is needed on this, though.
The keto diet works by eliminating carbohydrates from the your daily intake and keeping the body’s carbohydrate stores almost empty, therefore preventing too much insulin from being released following food consumption and creating normal blood sugar levels. This can help reverse “insulin resistance,” which is the underlying problem contributing to diabetes symptoms. In studies, low-carb diets have shown benefits for improving blood pressure, postprandial glycemia and insulin secretion. (7)
{Correction to my earlier comment above: The brain is able to use ketones as fuel, but when glucose is in short supply, the glucose permeability of the blood brain barrier increases by 1/3 to 1/2. And despite what the textbooks say, there is a pathway for converting fatty acids to glucose; it’s a fruitless pathway, because there is no net gain of glucose.}
Increased enterohepatic circulation on high fat means that cholesterol is kept "in play" - bounced back into the bloodstream in ApoB particles - while low enterohepatic circulation, in people with with higher synthesis rates, during weight loss - when cholesterol is being dumped by shrinking cells - means that cholesterol can pile up in the gall bladder faster than it can be conjugated to bile salts and bile acids and faster than it can be extracted by the weak stimulus of low fat food.
The original therapeutic diet for paediatric epilepsy provides just enough protein for body growth and repair, and sufficient calories[Note 1] to maintain the correct weight for age and height. The classic therapeutic ketogenic diet was developed for treatment of paediatric epilepsy in the 1920s and was widely used into the next decade, but its popularity waned with the introduction of effective anticonvulsant medications. This classic ketogenic diet contains a 4:1 ratio by weight of fat to combined protein and carbohydrate. This is achieved by excluding high-carbohydrate foods such as starchy fruits and vegetables, bread, pasta, grains, and sugar, while increasing the consumption of foods high in fat such as nuts, cream, and butter.[1] Most dietary fat is made of molecules called long-chain triglycerides (LCTs). However, medium-chain triglycerides (MCTs)—made from fatty acids with shorter carbon chains than LCTs—are more ketogenic. A variant of the classic diet known as the MCT ketogenic diet uses a form of coconut oil, which is rich in MCTs, to provide around half the calories. As less overall fat is needed in this variant of the diet, a greater proportion of carbohydrate and protein can be consumed, allowing a greater variety of food choices.[4][5]
Don’t expect to turn into a muscle-bound. There is unfortunate hype surrounding this diet. There are no magical “ketone” supplements that turn you thin. But studies show it might improve your thinking, help with type 2 diabetes, dementia, seizures and inflammation. Every diet has its detractors. Recent “news” has been particularly harsh with dramatic headlines. Some considered it a “fad.” Others question sustainability. So, are they right?
Recent studies show that low-carb diets such as keto are more effective at raising good (HDL) cholesterol than low-fat diets [1, 2]. However, there are also studies showing that keto can increase total cholesterol (HDL and LDL) [3]. On the other hand, low-carb, high-fat diets also decrease LDL particle concentration (LDL-P), increase the size of LDL cholesterol and decrease the amount of harmful VLDL cholesterol in the blood [2], all of which have a positive effect on cardiovascular fitness.
The Modified Atkins Diet (MAD) is one of these alternative diets. It is a less restrictive form of the ketogenic diet. Adults and adolescent patients are restricted to 20 grams of carbohydrates per day and children to 15 grams per day. This diet can be easier to tolerate especially in older children and adults who eat a normal diet. In the MAD, there are no restrictions on protein and calories (and the biggest difference is probably the protein compared to the ketogenic diet). Increased fat intake is encouraged to increase ketosis.
Hi Maya. I LOVE your site!! Interesting, informative with fab recipes and ideas. Hubby and I have just started eating low carb and I have to say, we are not finding it too difficult and I already feel sooo much better!! I find the hardest part is choosing low carb veg, I feel as if we are not eating enough. Any suggestions on how to get more veggies into our diet?
Along with slashing carbs, a ketogenic plan also calls for limiting your protein consumption. If you know your macronutrients, you recognize that cutting carbs and restricting protein means seriously upping your fat intake. And that’s exactly what a true ketogenic diet entails. “You’d want healthy fats to account for about 80% of your calories, and protein around 20%,” Westman says. (For comparison’s sake, the average American gets roughly 50% of her calories from carbs, 15% from protein, and 30% from fat, per the CDC.)
These preliminary findings spurred Dr. Good to encourage a more thorough investigation of Kelley’s methods and results. As the project grew in scope, I continued my “Kelley Study” in my spare time during the last two years of medical school, and ultimately brought it to completion while pursuing my immunology fellowship training under Dr. Good at All Childrens’ Hospital in St. Petersburg.
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In relation to overall caloric intake, carbohydrates comprise around 55% of the typical American diet, ranging from 200 to 350 g/day. The vast potential of refined carbohydrates to cause harmful effects were relatively neglected until recently. A greater intake of sugar-laden food is associated with a 44% increased prevalence of metabolic syndrome and obesity and a 26% increase in the risk of developing diabetes mellitus. In a 2012 study of all cardiometabolic deaths (heart disease, stroke, and type 2 diabetes) in the United States, an estimated 45.4% were associated with suboptimal intakes of 10 dietary factors. The largest estimated mortality was associated with high sodium intake (9.5%), followed by low intake of nuts and seeds (8.5%), high intake of processed meats (8.2%), low intake of omega-3 fats (7.8%), low intake of vegetables 7.6%), low intake of fruits (7.5%), and high intake of artificially sweetened beverages (7.4%). The lowest estimated mortality was associated with low polyunsaturated fats (2.3%) and unprocessed red meats (0.4%). In addition to this direct harm, excess consumption of low-quality carbohydrates may displace and leave no room in the diet for healthier foods like nuts, unprocessed grains,  fruits, and vegetables.
Failing to consume enough calories on a keto diet can cause fatigue and insomnia, while an insufficient protein intake promotes weight gain and muscle loss. When you first begin a keto diet, it can be helpful to track your food intake with an app such as Carb Manager Keto Diet App; this will allow you to visualize your macronutrient intake and ensure that you don’t undereat calories or protein. As I mentioned earlier, a low-protein intake is not required to obtain the benefits of keto. A sufficient protein intake (15 to 30 percent of total calories) suppresses hunger and, in most people, does not affect blood ketone levels. (43)

We have a dedicated dietitian who provides patients with individualized nutrition education, meal planning and resources, as well as recipes including some for ketogenic-friendly breads and desserts. Cooking classes and demonstrations for patients are also currently under development. Patients on dietary therapy will be closely monitored by a neurologist, Dr. Elizabeth Felton, who was trained in adult dietary therapy at The Johns Hopkins Hospital.
Serum cholesterol and triglycerides may increase, especially during the first 6 months. These levels may even out by 6 months, then decline often back to normal values. It is rare to stop the diet due to a cholesterol problem, especially after 1-2 years of use. Adjustments to the diet (e.g., increased protein and polyunsaturated fat) can be made in children with significantly high cholesterol and triglyceride concentrations.
High-protein ketogenic diet (HPKD): This version of the keto diet is often followed by folks who want to preserve their muscle mass like bodybuilders and older people. Rather than protein making up 20 percent of the diet, here it’s 30 percent. Meanwhile, fat goes down to 65 percent of the diet and carbs stay at 5 percent. (Caution: folks with kidney issues shouldn’t up their protein too much.)

Ketogenesis has existed as long as humans have. If you eat a very low amount of carbohydrates, you starve your brain of glucose, its main fuel source. Your body still needs fuel to function, so it taps into your reserve of ketones, which are compounds the liver creates from fat when blood insulin is low. This process is known as ketosis: It’s like when a hybrid car runs out of gas and reverts to pure electricity.
The total-to-HDL cholesterol ratio is found by dividing your total cholesterol level by your HDL-C, and it is essentially the same thing as an LDL-to-HDL cholesterol ratio since most non-HDL cholesterol is LDL cholesterol [26]. The researchers of the 2003 meta-analysis used this ratio because it is a better cardiovascular risk predictor than total cholesterol levels [25].
Increased enterohepatic circulation on high fat means that cholesterol is kept "in play" - bounced back into the bloodstream in ApoB particles - while low enterohepatic circulation, in people with with higher synthesis rates, during weight loss - when cholesterol is being dumped by shrinking cells - means that cholesterol can pile up in the gall bladder faster than it can be conjugated to bile salts and bile acids and faster than it can be extracted by the weak stimulus of low fat food.
A ketogenic diet has been observed to raise cortisol, the body’s primary stress hormone. If you struggle with high levels of stress or HPA axis dysfunction, a ketogenic diet may push your stress-response system into overdrive and cause burnout. A diet that includes a moderate intake of carbohydrates is typically a better fit for those with high-stress lifestyles or HPA axis dysfunction.

Calorie restriction, while more difficult than intermittent fasting for some, has shown promising results in preventing and starving cancer for the same reasons as intermittent fasting. Basically, calorie restriction will cause cancer to run itself out of fuel because of its constant need for glucose and lack of metabolic flexibility. Once that happens, the cancer may begin to starve and die off.


Bob, who knew Stefansson’s work well, told me during more than one dinner together in the late 1980s that the ketogenic diet might represent the ultimate solution to cancer. He thought, as Donaldson and Stefansson had claimed before him, that all humans should be following a ketogenic diet to achieve ultimate ideal health. But were they right? Or was there another, perhaps more accurate way, to look at the human dietary condition?
Throughout this experiment, you should either keep to a standard LCHF ratio (75% fat, 20% protein, 5% carbs) or one with an even higher proportion of fat (such as 80% or 85% fat). On low-calorie days you’d eat less than 1000 calories with the same macro ratios. On high-calorie days, you’d eat about 1000 calories above your maintenance with the same macros.
A ketogenic diet has been observed to raise cortisol, the body’s primary stress hormone. If you struggle with high levels of stress or HPA axis dysfunction, a ketogenic diet may push your stress-response system into overdrive and cause burnout. A diet that includes a moderate intake of carbohydrates is typically a better fit for those with high-stress lifestyles or HPA axis dysfunction.
Recent studies show that low-carb diets such as keto are more effective at raising good (HDL) cholesterol than low-fat diets [1, 2]. However, there are also studies showing that keto can increase total cholesterol (HDL and LDL) [3]. On the other hand, low-carb, high-fat diets also decrease LDL particle concentration (LDL-P), increase the size of LDL cholesterol and decrease the amount of harmful VLDL cholesterol in the blood [2], all of which have a positive effect on cardiovascular fitness. 

Seyfried agrees that there is clear evidence that cancer is a genetic disease, since we can inherit mutations that are clearly associated with increased cancer risk. That’s not at all controversial. That’s well established, and even Seyfried agrees with that. But he argues that many of these mutations that we can inherit are mutations that actually disturb cellular respiration, maybe that the heritable aspect of cancer is not mutation that drives itself—cellular proliferation—but instead are mutations that actually cause mitochondrial dysfunction and defects in cellular respiration. He also points out that many of the non-inherited causes of cancer that have been identified and are clearly recognized, like radiation, impair mitochondrial function. That may be a common mechanism that is shared between these non-inherited causes of cancer and inherited causes of cancer.
Before starting the diet, the patient should maintain a seizure diary to establish a frequency parameter. Also needed are a laboratory evaluation including selenium and carnitine levels (Table 5), electroencephalogram (EEG), and a magnetic resonance image (MRI) of the brain. A renal ultrasound should be done in case of kidney stones; an electrocardiogram and carotid ultrasound are considered optional (Kossoff et al., 2018). The nutritional evaluation includes a nutritional anamnesis including a 3-day food report, food habits, allergies, aversions, and intolerances. Baseline weight, height, and the ideal weight for stature and body mass index (BMI) are needed to calculate the ketogenic ratio, calories, and fluid intake. The diet formulation should be established according to the patient’s age and the administration route (Kossoff et al., 2009).

This brings me back to the question of whether cancer is a metabolic disease or a genetic disease, the answer to which I promised early on. The likely answer? It’s both! Indeed, a “chicken or the egg” argument continues about whether it is the metabolic abnormalities that cause the mutations observed in cancer cells or whether it is the mutations that produce the metabolic abnormalities. Most likely, it’s a little of both, the exact proportion of which depending upon the tumor cell, that combine in an unholy synergistic circle to drive cancer cells to be more and more abnormal and aggressive. Moreover, cancer is about far more than just the genomics or the metabolism of cancer cells. It’s also the immune system and the tumor microenvironment (the cells and connective tissue in which tumors arise and grow). As I’ve said time and time and time again, cancer is complicated, real complicated. The relative contributions of genetic mutations, metabolic derangements, immune cell dysfunction, and influences of the microenvironment are likely to vary depending upon the type of tumor and, as a consequence, require different treatments. In the end, as with many hyped cancer cures, the ketogenic diet might be helpful for some tumors and almost certainly won’t be helpful for others. Dr. Seyfried might be on to something, but he’s gone a bit off the deep end in apparently thinking that he’s found out something about cancer that no one else takes seriously—or has even thought of before.
Clinical improvement was observed in Alzheimer’s patients fed a ketogenic diet, and this was marked by improved mitochondrial function. (15) In fact, a European Journal of Clinical Nutrition study pointed to emerging data that suggested the therapeutic use of ketogenic diets for multiple neurological disorders beyond epilepsy and Alzheimer’s, including headaches, neurotrauma, Parkinson’s disease, sleep disorders, brain cancer, autism and multiple sclerosis. (16)
However, this doesn't happen in every case or even most cases. In fact, many people see little to no increase in their LDL cholesterol while experiencing beneficial changes in other markers, such as an increase in HDL cholesterol and a decrease in triglycerides, blood sugar, and insulin levels – all of which are associated with reduced risk of CVD.
The ketogenic diet is a medical nutrition therapy that involves participants from various disciplines. Team members include a registered paediatric dietitian who coordinates the diet programme; a paediatric neurologist who is experienced in offering the ketogenic diet; and a registered nurse who is familiar with childhood epilepsy. Additional help may come from a medical social worker who works with the family and a pharmacist who can advise on the carbohydrate content of medicines. Lastly, the parents and other caregivers must be educated in many aspects of the diet for it to be safely implemented.[5]
To identify which genes might be involved, the researchers used microarray "gene chips" to examine changes in gene expression for more than 7,000 rat genes simultaneously. They focused on the hippocampus, a region of the brain known to play an important role in many kinds of epilepsies. More than 500 of the genes they examined were correlated with treatment with the KD. The most striking finding was the coordinated up-regulation of genes involved in energy metabolism.
The first signs of ketosis are known as the “keto flu” where headaches, brain fogginess, fatigue, and the like can really rile your body up. Make sure that you’re drinking plenty of waterand eating plenty of salt. The ketogenic diet is a natural diuretic and you’ll be peeing more than normal. Take into account that you’re peeing out electrolytes, and you can guess that you’ll be having a thumping headache in no time. Keeping your salt intake and water intake high enough is very important, allowing your body to re-hydrate and re-supply your electrolytes. Doing this will help with the headaches, if not get rid of them completely.
A ketogenic diet is a very high-fat low-carbohydrate diet that is designed to induce fat metabolism. When the body is depleted of glucose stores, it shifts to metabolizing fat and fatty acids, which produces compounds called ketones. Ketones cross through the blood-brain barrier and enter the brain, where they’re used as an alternative energy source.
Having tempting, unhealthy foods in your home is one of the biggest reasons for failure when starting any diet. To maximize your chances of success with the keto diet, you need to remove as many triggers as you can. This crucial step will help prevent moments of weakness from ruining all your hard work.If you aren’t living alone, make sure to discuss with your family or housemates before throwing anything out. If some items are simply not yours to throw out, try to compromise and agree on a special location so you can keep them out of sight.
A meta-analysis of 13 randomized controlled trials following overweight and obese participants for 1-2 years on either low-fat diets or very-low-carbohydrate ketogenic diets found that the ketogenic diet produced a small but significantly greater reduction in weight, triglycerides, and blood pressure, and a greater increase in HDL and LDL cholesterol compared with the low-fat diet at one year. [10] The authors acknowledged the small weight loss difference between the two diets of about 2 pounds, and that compliance to the ketogenic diet declined over time, which may have explained the more significant difference at one year but not at two years (the authors did not provide additional data on this).
On the other hand, higher HDL cholesterol levels have been linked to less carotid artery intima-media thickness. In a large meta-analysis of data from more than 20,000 people, CIMT tended to decrease as HDL cholesterol increased – regardless of LDL cholesterol values (16). Importantly, although LDL response to carb restriction varies from person to person, HDL virtually always increases.
A popular alternative that helps many is called the Modified Atkins Diet. This diet is far less restrictive, as calories, fluids, and protein are not measured. The diet begins with 10 grams of carbohydrate per day for the first month, and then slowly moving to 15 or 20 grams. It is similar to a very strict induction phase of Atkins. There has been at least one study, though, where some achieved better seizure control when they switched from the Atkins diet to the KDE.
In many developing countries, the ketogenic diet is expensive because dairy fats and meat are more expensive than grain, fruit and vegetables. The modified Atkins diet has been proposed as a lower-cost alternative for those countries; the slightly more expensive food bill can be offset by a reduction in pharmaceutical costs if the diet is successful. The modified Atkins diet is less complex to explain and prepare and requires less support from a dietitian.[55]
The ketogenic diet, or even just a higher-fat, low-carb diet, has now gained massive support as a modern-day healing strategy. In fact, our ideas about fats and cholesterol seem to have been almost completely reversed in recent years. That being said, many people see their cholesterol go up after beginning more of a ketogenic lifestyle. Some people get concerned when this happens, so in this article, I am going to address the phenomena of high cholesterol on a ketogenic diet.
Jimmy Moore: That’s exactly what’s happening inside your body when you have less cholesterol and you have higher levels of inflammation in your body. You’re putting your body at risk because those fire fighters aren’t there. The cholesterol to put out the fire of inflammation and so we really have to know where we stand with inflammation and without the inflammation, there really is no heart disease. People are, “Oh you have 289 total cholesterol, you’re at great risk for heart disease.”
Usually the body uses glucose (a form of sugar) from carbohydrates (found in foods like sugar, bread or pasta) for its energy source. Chemicals called ketones are made when the body uses fat for energy (this is called ‘ketosis’). With the ketogenic diet, the body mostly uses ketones instead of glucose for its energy source. Research has shown that a particular fatty acid, decanoic acid, may be involved in the way the diet works. 
Keto will increase your cholesterol, because your body is getting more cholesterol from food. So guess what your body will do when you increase the dietary cholesterol…that’s right, it’ll stop producing its own cholesterol. Since 75% of your cholesterol is made inside your body, if you increase the amount that you eat, your body will cut that 75% down. Your body isn’t stupid. It knows what it needs.
Based on this logic, the keto diet appears to be a safe, inexpensive, easily implementable, and effective approach to selectively target cancer cells. Promisingly, multiple studies show that the keto diet reduces tumor growth and improves survival in animal models of multiple cancers, along with enhancing the effects of other forms of anticancer therapy.11,15 Similarly, fasting has been shown to enhance responsiveness to chemotherapy, along with reducing some of the side effects in preclinical cancer therapy models.11
The Epilepsy Foundation has acknowledged the KD as a treatment option and provides an educational summary about the diet on its website. It’s encouraging that a major patient advocacy group is willing to publish information about a treatment option far from common practice. The health care professional is responsible for being aware of various patient treatment options so the best care possible is provided.
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When ketones are present in the body fluids at elevated concentrations, a person is said to be in ketosis. Dietary ketosis is a normal physiological response to sustained low carbohydrate intake that results in lowered blood glucose and insulin levels and stimulates the production of something known as ketone bodies. During ketosis, fats, either from the diet or from body stores, become the obligatory source of cellular energy for most body tissues while ketone bodies are produced in the liver to supply the rest of the body’s energy needs.4 Dietary ketosis should not be confused with diabetic ketoacidosis, a pathological condition that occurs mainly in type I diabetics due to an acute severe insulin deficiency (usually due to missing insulin injections) and a resulting inability to use glucose, though it is abundant. During diabetic ketoacidosis, blood ketone levels can be as high as 10-15 mM/l (significantly higher than what can be achieved in dietary ketosis). As ketone production exceeds the tissues’ ability to use them, the ketones build up and the blood pH is lowered.5 Immediate medical attention is required to prevent serious complications. This document deals with dietary ketosis only.
Then there are some more experimental drugs that restrict the availability of glucose via inhibition of glycolysis and other processes. One of those drugs is called 2-DG, and that’s shown quite a bit of promise, so there’s not a lot of research on it yet, and then there’s an older drug named DCA, which also limits the availability of glucose. That has shown some promise, although it has known toxicity and side effects. It may not be a good choice for that reason.

The digestion of carbohydrates (sugar and starch) releases sugar (glucose) into the bloodstream. Greater carb intake results in rising blood sugar and insulin, a pancreatic hormone that manages blood sugar.  Going keto replaces dietary carb with fat and protein. Over time, your cells switch metabolic pathways, and burn stored and dietary fat as a primary energy source instead of sugar. As more fat is burned, some of it is converted into ketone bodies. As blood glucose and insulin levels fall, and ketone levels rise, your muscles (skeletal and heart), use the fats in the bloodstream as fuel, while your brain uses the ketones. The result is more energy, clearer thinking and better health. Ketones are beneficial in many different ways, and being in this metabolic state of "nutritional ketosis" (where blood sugar is low and ketone levels are moderate) has some powerful effects on your metabolism. There is strong research evidence that these metabolic-affecting diets can be used to treat the following medical conditions:


The oxygen-free pathway used by cancer cells needs a lot more glucose to produce the same amount of energy as an oxygen-using cell. This realization led to imaging techniques where cancer cells can be detected by spotting where large amounts of a glucose tracer accumulate in the body. The glucose used in this technique contains a small amount of radioactive material that lights up in the image.
The popular belief that high-fat diets cause obesity and several other diseases such as coronary heart disease, diabetes, and cancer has not been observed in recent epidemiological studies. Studies carried out in animals that were fed high-fat diets did not show a specific causal relationship between dietary fat and obesity. On the contrary, very-low-carbohydrate and high-fat diets such as the ketogenic diet have shown to beneficial to weight loss.
A: The amount of weight you lose is entirely dependent on you. Obviously adding exercise to your regimen will speed up your weight loss. Cutting out things that are common “stall” causes is also a good thing. Artificial sweeteners, dairy, wheat products and by-products (wheat gluten, wheat flours, and anything with an identifiable wheat product in it).

When you first embark on a ketogenic diet, your goal is to be in nutritional ketosis consistently. Over time, as you train your body to function on fewer carbohydrates, you may enter the fat adaptation phase. While ketosis can be achieved after just a few days of the diet, at least three to four weeks of strict adherence to the diet is required in order to reach the fat adaptation state. This is also the time frame during which you’ll likely begin to notice benefits of the diet.


Dr. Campos, it is so discouraging to see that you disparage the ketogenic diet based on your assumption that it is very heavy in poor quality processed meats. No diet that relies on processed foods can be viewed as “healthy”. Become better informed by getting up to speed with what Jeff Volek, RD, PhD, calls a “well-formulated ketogenic diet.” Also, learn more about the potential of the diet to slow cancer progression (my specialty). You owe it to your patients who are depending on you for advice. Present them with facts, not opinions.
As you might suspect, this metabolic theory of cancers is controversial in the mainstream cancer paradigm, but there’s already promising initial evidence to support it, and most traditional cancer specialists concede that this metabolic theory has merit, and it may be a piece of the puzzle. I would say that the dominant paradigm idea right now is that metabolic dysfunction is likely one of the pieces of the puzzle, but that cancer is multifactorial and probably does involve genetic mutations that may be independent of metabolic dysfunction and that there are other causes that may not be directly related to metabolic dysfunction.
Jimmy Moore: Or B-B sized, exactly. You can have that particular test run to see all the sub-fractions of your LDL. It’s called NMR lipo profile, it’s only 1 lab in the entire world that does it, they’re in Raleigh, North Carolina called Lipo Science. Your doctor again, any doctor can run the NMR lipid profile test, and it shows you all the typical things that you see … HDL, triglycerides, all that is on this test as well but you get that LDL particle size breakdown. You get the total particle number, which is called LDLP, and then you get small LDLP and that’s the one you want as low as possible.

After increasing water intake and replacing electrolytes, it should relieve most all symptoms of Keto Flu. For an average person that is starting a ketogenic diet, eating 20-30g of net carbs a day, the entire adaptation process will take about 4-5 days. My advice is to cut your carbs to fewer than 15g to ensure that you are well on your way into ketosis within one week. If you are experiencing any more keto flu symptoms, double check your electrolyte intake and adjust.
In 1970, Robert C. Atkins developed a weight-loss diet that restricted the intake of carbohydrates (Sharma and Jain, 2014), and this diet was later evaluated for seizure treatment. The first patient was a 7-year-old girl with intractable epilepsy due to a left parietal cortical dysplasia, who used the Atkins diet for a week in order to acclimate to the CKD. After 3 days, her seizures stopped, and she remained seizure-free for 3 years with continued dietary treatment (Kossoff et al., 2013). In 2006, this diet was first formally referred to as the “MAD” to distinguish it from the Atkins diet (Kossoff et al., 2013). The MAD has three significant differences from the first version: the induction phase of limiting carbohydrates is maintained indefinitely; high-fat foods are not only allowed, but encouraged; and the primary goal of the diet is seizure control (Atkins, 2002; Sharma and Jain, 2014).
For an estimated 25 to 30% of people – whether weight loss occurs or not – LDL cholesterol goes up significantly in response to very-low-carb diets, sometimes by 200% or more. Many of these folks seem to belong to a group that Dave Feldman at Cholesterol Code refers to as lean mass hyper-responders (LMHRs). These often healthy people are sometimes shocked to discover that their LDL cholesterol has soared above 200 mg/dL (5.2 mmol/L) after going keto.
Most condiments below range from 0.5–2 net carb grams per 1–2 tablespoon serving. Check ingredient labels to make sure added sugar is not included, which will increase net carbs. (Stevia and erythritol will become your go-to sweeteners because neither raise your blood sugar — combine for a more natural sweet taste and, remember, a little goes a long way!)
And finally, there is increasing debate over the importance of the standard (i.e., calculated) LDL cholesterol level relative to the sum of other cardiovascular risk factors. This controversy makes it difficult for the individual patient to weigh the evidence from the various known risk factors. If you are uncertain, it is a good idea to follow up with your physician, who may recommend performing the most up-to-date assessment of your blood lipids, including the size and amounts of your LDL cholesterol fractions with a NMR or VAP lipoprotein test.
Scientists published the first pilot study on the relationship between the ketogenic diet and cancer in 2011. For their study, they recruited 16 patients (12 women and 4 men) with various cancers in advanced stages. They had an average age of 50.4 years (30-65 years). All of them had metastatic tumors, which means that they grew and spread throughout the body.
At the time I finished my monograph in 1986, I hoped that with its publication, fair-minded researchers might begin taking Dr. Kelley and his nutritional therapy seriously. As I was to learn, I completely and rather naively misjudged the animus of the scientific community toward unconventional cancer treatment approaches that didn’t fit the “accepted” model. Even with Dr. Good’s support, after two years of trying I could not get the book published, either in its entirety, or in the form of individual case reports appropriate for the conventional medical journals.
Unfortunately that’s wrong. Unfortunately total cholesterol doesn’t tell the whole story. It includes one number that you want to have higher. That is you HDL good cholesterol. When you start eating low carb, high fat, keto, one of the tell tale signs that you’ve done it very well is your HDL, especially you ladies, you’re lucky Leanne … you ladies can make your HDL just go really high. I have to work hard as a guy to get mine in the 70-80 range, which is pretty good for a guy. Most people walking around their HDL is sub 40, and most of them probably sub 20 if they’re not eating enough fat. You have to eat saturated fat in order to raise that good HDL cholesterol. Okay?
Within 7 days of initiating the ketogenic diet, blood glucose levels declined to low-normal levels and blood ketones were elevated twenty to thirty fold. Results of PET scans indicated a 21.8% average decrease in glucose uptake at the tumor site in both subjects. One patient exhibited significant clinical improvements in mood and new skill development during the study. She continued the ketogenic diet for an additional twelve months, remaining free of disease progression.

Teens and young adults who are becoming more independent often find the ketogenic diet too difficult to follow. Dietary options for epilepsy have expanded in recent years to include the modified Atkins diet and the low-glycemic index treatment diet. The latter diet does not necessarily cause ketosis, and may instead curb seizures by lowering glucose levels in the blood and possibly in brain cells.


Ketogenic diets represent a far more effective strategy for managing type 2 diabetes than the American Diabetes Association’s high-carb, low-fat dietary guidelines. Unlike the ADA’s guidelines, a ketogenic diet significantly reduces blood sugar, hemoglobin A1c levels, waist circumference, and triglycerides in diabetic individuals. (13) Most importantly, research indicates that the diet is sustainable for diabetic patients and that the beneficial changes can be maintained over the long term. (14)
Jimmy Moore: The thing here is I also always had high cholesterol. Cholesterol goes to … think of cholesterol like a fire fighter and inflammation is the fire. If a fire fighter goes to the scene of a fire, blows the water onto … you burning the house and it puts it out. Let’s say the neighbors house is on fire, and there’s no fire fighter that comes, what happens? Destruction, right?
I’m 46 and just had my cholesterol checked for the first time since I was 30. When I took it at 30 I hadn’t fasted and it was 133. Todays results came in at 242! Ive been doing Keto now for almost 2 years. I freaked out at first but after reading some articles I’m starting to feel better about my numbers. I won’t bore you with them but from all I’ve read I’m not at risk for heart disease as I first thought. Thanks for everyone who commented above, you’ve helped calm me 🙂
Except that it really isn’t, at least not anymore. If you do a Pubmed search on “targeting cancer metabolism,” which is what Dr. Seyfried is talking about, you’ll find over 22,000 articles, with over 3,000 in 2013 alone, with a sharply increasing curve since 2000 that only now appears to be leveling off. A search on “cancer metabolism” brings up 369,000 references, with 28,000 in 2013 alone. Cancer metabolism is an incredibly important topic in cancer research and has been for several years now, and finding means of targeting the common metabolic abnormalities exhibited by cancer cells is currently a hot area of research. From my perspective, Dr. Seyfried is exaggerating how hostile the cancer research community is towards metabolism as an important, possibly critical, driver of cancer, although, to be fair, one prominent cancer researcher, Robert Weinberg, has been very skeptical. To me, Seyfried just appears unhappy that genetics is currently thought—for good reasons, I might add—to be the primary driver of most cancers. Note that I intentionally used such phrasing, because Dr. Seyfried, in my readings, appears all too often to speak of “cancer” as if it were a monolithic single disease. As I’ve pointed out many times before, it’s not. Indeed, only approximately 60-90% of cancers demonstrate the Warburg effect.

Its hard to find any information about hyper responders, even harder for me as my total cholestorl levels increased extremely after I went on the keto diet, from an already high 5mmol/dL to extremely high (14mmol/dL or 538mg) which is unheard of, even in the many hyper responder cases I've studied. But my HDL increased to 2.7mmol and my trigicerides stayed the same at good 0.9. Nobody 've seen has such a high total cholestrol. Even as i research how cholestrol doesn't have much link to heart disease mortality, there's no research on anything as high as my case.
The book summarizes, then enlarges upon, the concepts of Otto Warburg, MD, the great German scientist who won the Nobel Prize in Medicine and Physiology in 1931 for his work on cellular oxidation and energy production. No scientist has ever been nominated more frequently for the cherished Prize than Dr. Warburg, but he lost his chance for a second win, according to some sources, in 1944 after Hitler ordered that no German scientist could accept the award.
A popular keto supplement are exogenous ketones (popularly called “keto diet pills”) that may help you achieve results earlier as well as remain in that state. (Don’t confuse exogenous ketones with raspberry ketones, as the latter don’t raise ketone levels in the body or mimic endogenous ketones, so you wouldn’t use raspberry ketones in your regimen.)

Any recommendations on cookbooks? I just purchased Simply Keto and the author uses what seems an abundance of processed meats which have highly toxic cancer causing sodium. Also, the sweeteners suggested rather then sugar are also highly toxic cancer causing…and so on. I am trying to cancel my order so I can research more on recipes, using foods that truly are healthy and not causing cancer in itself, losing weight is not my priority and seems these cookbooks are more focused on losing weight not fighting cancer. The list of foods provided could not be complete, so if you are going to guide people to Keto lifestyle (I hate using the word “diet”) please provide more information such as those in the know and can trust recipes and guidance with complete list of foods and so on. Thank you in advance.
The first edition of this book was released in 2012 and was the first book written to help the patient. It has been updated as the research has developed, and the body of scientific evidence continues to grow. Metabolic therapy is cutting edge, and thousands of people have purchased and used the information in this book to take back some control over their own health. You can too.
If your LDL cholesterol has significantly increased on a keto or low-carb diet, it's completely understandable if you're at least somewhat concerned. However, you might be reluctant to make any changes to your diet given the benefits you've experienced. On the other hand, you may decide that you want to try to lower your LDL values while still following a keto/low-carb lifestyle.
On the other hand, higher HDL cholesterol levels have been linked to less carotid artery intima-media thickness. In a large meta-analysis of data from more than 20,000 people, CIMT tended to decrease as HDL cholesterol increased – regardless of LDL cholesterol values (16). Importantly, although LDL response to carb restriction varies from person to person, HDL virtually always increases.
This week we’re getting stricter with our fasting. We had a full week of intermittent fasting and now we’re going to skip breakfast and lunch. Water is our BEST friend here! Don’t forget that you can drink coffee, tea, flavored water, and the like to get your liquids in. Keep drinking to make sure you’re not thinking about your stomach. It MIGHT start growling, just ignore it – your body will adjust with time.
It’s not heart healthy because it’s raising inflammation. The reason they put in on there though is it does one thing on your cholesterol panel that they think is good. It lowers the LDLC number. It does. It will do it all day everyday. You can sit there and drink Canola oil, and your LDL will go down, your LDLC. That LDLC is just a calculated number using this thing called the Friedewald equation and it’s not directly measured. That’s another thing people don’t realize. LDLC is just totally an estimated number. When your triglycerides are under 100 and your HDL is over 50, it totally miscalculates what your LDL is. That’s why that NMR lipo profile test to know the particles is so important. I know I’m talking fast and saying a lot of technical terms.
The ketogenic or “keto” diet is a low-carbohydrate, fat-rich eating plan that has been used for centuries to treat specific medical conditions. In the 19th century, the ketogenic diet was commonly used to help control diabetes. In 1920 it was introduced as an effective treatment for epilepsy in children in whom medication was ineffective. The ketogenic diet has also been tested and used in closely monitored settings for cancer, diabetes, polycystic ovary syndrome, and Alzheimer’s disease.
If your child is helped by the diet and seizures are better controlled, your child may remain on the ketogenic diet for 2 to 3 years, or longer. The length of time on the diet will be determined by several factors, including how well the diet helps your child, whether your child can be weaned off seizure medications, and your willingness to continue the diet. 
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