As Stefansson and later scientists learned, the Eskimos living on their high fat, ketogenic diet seemed free from the typical degenerative diseases including cancer and heart disease, already becoming rampant in the Western world during the early decades of the 20th century. In 1960, the elderly Stefansson – was quite a celebrity by that time for his adventures to far away places – wrote a book entitled Cancer: Disease of Civilization?, in which he made the case that the typical Eskimo diet offered complete protection from this frightening malady.
Further, the authors revealed that only 60 to 65% of patients with epilepsy become seizure free using medication while 35% are resistant to the effects of medication. And they used these statistics to justify this study. They further stated that there has been an “exponential” growth in interest in using the ketogenic diet for the treatment of epilepsy.

This has been very comforting for me to read as I’ve been on a Keto diet for 8mo, loving my results which were weight loss (initially) but now the sustained clarity & sharpness of mind. I am lean (58kg) and very active. I had a blood test last week just to see where I’m at & my LDL is very high. Of course my doctor wants me to stop Keto but I just feel so great. I’m torn...
A recent 2017 study of over 2,500 adults looked at fasting insulin and high-sensitivity C-reactive protein (hs-CRP), an inflammatory marker considered a strong predictor of heart attack risk. In this study, people with the highest insulin levels were more than four times as likely to have an elevated hs-CRP value compared to those with the lowest insulin levels. By contrast, elevated LDL cholesterol levels showed no association with hs-CRP (4).

I think we obsess about numbers because we have been given a range that is supposedly the healthy, right range. Unfortunately there are a lot of mechanisms that we don’t know a lot about right now, that could be going on that makes that happen for some people in the mornings. I’ve just talked to too many of the experts, who say “Don’t worry about that. It’s really not the big deal. Keep an eye on your fasting insulin levels in the morning and even if you want to do a five hour glucose tolerance test, it’s call a 5 hour GTT, could go down to your doctor, please don’t drink that crappy glucose serum, because that will mess you up.” I actually did it one time with my co-author, he actually ran it with me … I wanted to see what would happen to my blood sugar and insulin levels when I had a low carb meal.
The mainstay of treatment for epilepsy is pharmaceutical intervention. As I recently noted, more and more we are seeing surgical procedures being performed for those individuals who have not had a significant improvement with drugs. I indicated that at least some individuals are gluten sensitive and may benefit from a gluten-free diet which potentially could keep them from undergoing potentially life-threatening surgery as a treatment for their epilepsy.
However, this doesn't happen in every case or even most cases. In fact, many people see little to no increase in their LDL cholesterol while experiencing beneficial changes in other markers, such as an increase in HDL cholesterol and a decrease in triglycerides, blood sugar, and insulin levels – all of which are associated with reduced risk of CVD.

If a person with familial hypercholesterolemia is then put on a high-fat diet,  they will become even more vulnerable to heart disease as the increased saturated fat and cholesterol content of the diet provokes higher cholesterol levels. And it gets even worse — since this person lacks the ability to clear LDL cholesterol out of their blood normally — their cholesterol levels will stay elevated for an even longer period of time. This will make it much more likely that the LDL particles will become damaged and stimulate plaque build up in the blood vessels.


The current body of research on metabolic cancer treatments using a keto diet continues to grow. Keto or metabolic cancer therapy is somewhat different than the treatment for other illnesses, and is discussed in detail in my book Fight Cancer with a Ketogenic Diet, which is based on the metabolic therapy research of Dr. Thomas Seyfried  and Dr. Dominic D'Agostino. The main idea behind the use of a ketogenic diet to treat cancer is to starve cancer cells of the sugar and other fuels they need to survive, and to provide support and protection for normal energy processes in healthy cells. The advantage of this treatment protocol is that it is non-toxic to the body, and in "wait and see" cases, it can provide an major health support advantage to the patient. The book was written for the patient and has all the details and research in an easy-to-use format.
Other genetic disorders caused by mutations limit the availability of energy substrates but do not necessarily cause seizures. One such disease is phosphofructokinase (PFK) deficiency. PFK is the rate-limiting enzyme in glycolysis for the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate. Patients with mutations in the muscle isoform of PFK demonstrate exercise intolerance with myalgias and stiffness. There also are rare infantile forms, such as a case reported by Swoboda et al. [21, Class III], with myopathy and arthrogryposis. This patient displayed marked gains in muscle strength and improvement in his developmental milestones after being placed on the ketogenic diet.
I actually went on a ketogenic diet last year to see if it would help my migraines. I have a history of chronic migraines which would usually last 3 days, sometimes longer. Triptans help a lot but I don’t like having to take them. I stayed in ketosis for about 8 months and experienced a significant reduction in migraines, from feeling some type of headache (mild o r severe) almost everyday to 1 or 2x per month while in ketosis. Although I’m very healthy otherwise, I do think my migraines may have something to do with blood sugar fluctuations (despite previously eating a whole foods diet and no refined carbs), and keto totally stabilized this. I eventually came off of Keto because I’m not really a meat lover. When I came off, but remained low carb, my migraines stayed under control for the most part. When I increase carbs, they do return.
Westman’s research on carb-restricted diets suggests they can help reduce appetite, spur weight loss and improve markers of heart disease. His findings aren’t outliers. From Atkins and South Beach to Mediterranean and Zone, low-carb, high-fat diets—or “LCHF” plans—are all the rage, and growing evidence suggests they’re a big improvement on the typical carb-heavy American diet. But the “keto” diet is the most carb-restrictive member of the LCHF gang.
Stem cells, wherever they may be found, can adapt quite nicely, and are far more flexible than originally believed. In laboratory animals, a liver stem cell placed into the bone marrow starts creating not liver, but bone marrow cells, a bone marrow stem cell transplanted into the liver begins to generate not bone marrow, but liver cells. The environment appears to be the key, ultimately determining the direction of stem cell development.
Basically, carbohydrates are the primary source of energy production in body tissues. When the body is deprived of carbohydrates due to reducing intake to less than 50g per day, insulin secretion is significantly reduced and the body enters a catabolic state. Glycogen stores deplete, forcing the body to go through certain metabolic changes. Two metabolic processes come into action when there is low carbohydrate availability in body tissues: gluconeogenesis and ketogenesis.[4][5]
A study with an intent-to-treat prospective design was published in 1998 by a team from the Johns Hopkins Hospital[20] and followed-up by a report published in 2001.[21] As with most studies of the ketogenic diet, no control group (patients who did not receive the treatment) was used. The study enrolled 150 children. After three months, 83% of them were still on the diet, 26% had experienced a good reduction in seizures, 31% had had an excellent reduction, and 3% were seizure-free.[Note 7] At 12 months, 55% were still on the diet, 23% had a good response, 20% had an excellent response, and 7% were seizure-free. Those who had discontinued the diet by this stage did so because it was ineffective, too restrictive, or due to illness, and most of those who remained were benefiting from it. The percentage of those still on the diet at two, three, and four years was 39%, 20%, and 12%, respectively. During this period, the most common reason for discontinuing the diet was because the children had become seizure-free or significantly better. At four years, 16% of the original 150 children had a good reduction in seizure frequency, 14% had an excellent reduction, and 13% were seizure-free, though these figures include many who were no longer on the diet. Those remaining on the diet after this duration were typically not seizure-free, but had had an excellent response.[21][22]
What we haven’t talked about is what raised inflammation yet. It’s two main things. I call them the twin villains in your health. Number one is, not surprising coming out of my mouth, carbohydrates are dastardly, especially the refined ones. Grains, starches, sugars, they’re just bad news for you and avoid if at all possible because they’re going to raise your inflammation the most. The second one, a lot of my low carb, keto friends are still eating. It disappoints me Leanne, because I think they don’t realize the negative impact that they’re having. It’s in just about every packaged food, even the so called low carb, keto foods. That’s vegetable oils. You really have to eliminate Canola oil, soy bean oil, cotton seed oil, corn oil … I don’t care if the American Heart Association has their stupid heart health symbol on it, it’s not heart healthy. The reason it’s not heart healthy … I’ll tell you why it’s heart healthy in a minute, why they think it is.
Jimmy Moore: I did not say that. You see my Instagram account, you know how much I hate processed boxed food. The mono unsaturated fats are avocados, avocado oil, 100% olive oil … that’s key too, make sure your getting olive oil that you know is 100% olive oil, because they can sneak in some of those omega-six facts into there and not tell anybody. That screws people up trying to avoid those. Of course, nuts have mono unsaturated fats as well. You can get a well rounded amount of fat from varying sources and that is really what’s going to help you in controlling your blood sugar, controlling your cholesterol, and controlling your inflammation.
The most convincing piece of evidence can be found in a 2003 meta-analysis. In this meta-analysis, researchers compiled the data from sixty trials that quantified the effect that feeding different types of fats to humans had on the total-to-HDL cholesterol ratio [25]. But before we look through the results, we must first understand what this ratio is.
Additionally, HDL cholesterol may have anti-inflammatory effects. A recent research study published by De Nardo et al shows that HDL may be responsible in reducing inflammatory activity by regulating immune system cells called macrophages. [5] Furthermore, epidemiological studies have noted an inverse association between levels of HDL and certain forms of cancer. [6, 7]
Thank you very much, Betsy, for mentioning Dr. Gonzales and his views on the ketogenic diet. We had not heard of Dr. Gonzales before this. In preparing for our reply to you, we found your and your husband Bruce’s website dedicated to healing and restoring personal relationships. We mention this because we do not recall ever receiving a comment from anyone other than health care professionals or people concerned about their own nutrition.
Bob wasn’t the only physician, his clinic not the only place, where the ketogenic diet has been applied in modern times. At the Johns Hopkins Medical Center, for many years a group of researchers and neurologists have prescribed a very strict ketogenic diet for children with intractable seizures, that is, seizures unresponsive to currently available medications. For this particular indication, in adults as well as children, the diet works quite well.
Overall, cancer is a complex disease with many causes and contributors, but it is becoming less mysterious and more understandable as more research is done. Cancer can develop multiple traits that make it more and more resilient, but we also keep making more and more discoveries that provide us with clues as to how we can prevent, manage, and treat various types of cancer — even those that are the most sinister.
Our regimen is a modification of the classic ketogenic diet, similar to the Atkins diet. Recent studies have shown that this modified Atkins diet lowers seizure rates in nearly half of adults that try it, usually within a few months. Unlike the ketogenic diet for children, this therapy does not require a hospital stay, an initial fasting period, food weighing, fluid measuring, or calorie counting.
Calorie restriction (CR) and a ketogenic diet (KD) target the same molecular pathways that are also targeted individually by drugs to improve cancer treatment outcomes. Arrows indicate activation, truncated lines inhibition. Carbohydrate (CHO) restriction up-regulates fatty acid oxidation and ketogenesis (beneficial for normal tissues) and impairs glycolysis and glutaminolysis (detrimental to tumor cells). Full study here.
Unfortunately, there’s no long-term data on ketogenic diets versus other diets. In a 2015 Italian study, those on a ketosis diet lost 26 pounds in three months. About half of the participants stayed on the diet for a year but lost little additional weight in the next nine months. People in a 2014 Spanish study who followed a very-low-calorie ketogenic diet lost an average of 44 pounds in a year—but a third of them dropped out, possibly because it was too hard to maintain.
Lazy keto diet: Last but not least, the Lazy keto diet often gets confused with dirty keto … but they’re different, as the “lazy” refers to simply not carefully tracking the fat and protein macros (or calories, for that matter). Meanwhile, the one aspect that remains strict? Not eating over 20 net carb grams per day. Some people find this version less intimidating to start with or end with … but I will caution that your results will be less impressive.
A recent 2017 study of over 2,500 adults looked at fasting insulin and high-sensitivity C-reactive protein (hs-CRP), an inflammatory marker considered a strong predictor of heart attack risk. In this study, people with the highest insulin levels were more than four times as likely to have an elevated hs-CRP value compared to those with the lowest insulin levels. By contrast, elevated LDL cholesterol levels showed no association with hs-CRP (4).
My Husband and I started doing Keto July 2018. We got over weight after we got out of the Marine Corps. It has been hard to workout because I became disabled, but my diet was not good. After our friend Amber recommended your site and support group, we found a lot of helpful information to get us started on a successful journey. So far it’s been one month and we have lost 18 pounds each!
Jimmy Moore: Yeah, so in Cholesterol Clarity, we focused on two primary fats. That is the saturated fats, and the mono unsaturated fats, I also throw the omega-three fats in there as well. Obviously you want to get those into you. What’s interesting is people will see a steak for example, they’ll say “Oh, that’s all saturated fat.” No it’s not. It’s about half mono unsaturated fat, and about half saturated fat and has a little bit of poly in there as well. I don’t think you need to go out of your way to necessarily add in poly unsaturated fats, those fats come … omega-six fats specifically come from things like nuts. You get enough. What we’re trying to do is shift that ratio.

The ketogenic diet is designed to allow an individual to feel satisfied easily as a result of optimal insulin and leptin sensitivity. For example, a man weighing 150 pounds should consume 30-50g/day of carbohydrates and less than 70g/day of protein to maintain an optimal state of ketosis. When only a single meal or two is consumed consisting of approved ketogenic foods, this is easy. The ideal blood sugar concentration for weakening cancer cells is between 60-70mg/dl, and ketone levels are recommended between 4-7mM.


When your body burns its stores of fat, it can be hard on your kidneys. And starting a ketogenic diet -- or going back to a normal diet afterward -- can be tricky if you’re obese because of other health issues you’re likely to have, like diabetes, a heart condition, or high blood pressure. If you have any of these conditions, make diet changes slowly and only with the guidance of your doctor.
One theory is that an extreme increase in cholesterol may be common in those undergoing rapid weight loss. This is because the fat cells we have stored in our adipose tissue contain high amounts of both triglycerides and cholesterol. When we begin to break down our stored fat to be metabolized for energy, cholesterol in the blood goes up temporarily.
The anti-angiogenesis love affair not only affected conventional researchers and oncologists, but infiltrated deeply into the “alternative” cancer world. During the late 1990s, I read numerous articles lauding the anti-angiogenic effect of various herbs. Some ten years ago or more, a number of alternative physicians began promoting artemesinin, an herb from Africa long used as a treatment for malaria, as a “natural” anti-angiogenesis supplement.
When a person first starts onto a low-carbohydrate ketogenic diet, it takes the body several days to a few weeks to shift from relying on glucose to instead rely on fat. During this transition, people may experience what is sometimes referred to as the “keto-flu”—muscle cramps, headaches, fatigue, dizziness, nausea, and sugar and carbohydrate cravings.49 There may also be increased urination which can result in a loss of minerals, such as sodium and potassium. To counter these effects one should strive to get more minerals and in particular, more sodium and potassium, drink plenty of water, get some exercise and ensure adequate caloric intake. Once the body becomes keto-adapted, these symptoms largely resolve, and many people report increased energy, decreased cravings and weight loss.

Within 7 days of initiating the ketogenic diet, blood glucose levels declined to low-normal levels and blood ketones were elevated twenty to thirty fold. Results of PET scans indicated a 21.8% average decrease in glucose uptake at the tumor site in both subjects. One patient exhibited significant clinical improvements in mood and new skill development during the study. She continued the ketogenic diet for an additional twelve months, remaining free of disease progression.
firstly, the LMHR profile also applies to long-term fasting studies - this is perhaps where it can be observed in its natural, unconfounded state - LDL rises in lean healthy individuals during a fast, but drops or stays stable in those with obesity or atherosclerosis (period varies from 3-21 days). This is consistent with the keto pattern; this evidence clearly shows that LDL divergence is related to burning a high % of fat, and not to eating it, which is to some extent a confounder with keto (as shown by the cholesterol drop protocol and the possible different effects of different fat types and amounts).
I’ve been Keto for over a year now. I’ve lost 60 lbs. I’m off Metformin for type 2 diabetic and my LDL has improved significantly. In my experience, Keto will show some quick results in some but for others it will take longer. It depends on how long you’ve been on the standard American diet. It will take time for your body to fix “self-heal”. Not everyone will have the same results in the same amount of time.
The first edition of this book was released in 2012 and was the first book written to help the patient. It has been updated as the research has developed, and the body of scientific evidence continues to grow. Metabolic therapy is cutting edge, and thousands of people have purchased and used the information in this book to take back some control over their own health. You can too.
Recommendation: If you are looking to optimize your cholesterol levels and reduce your cardiovascular disease risk, a ketogenic diet that mainly consists of coconut oil, olive oil, avocados, nuts, fish, and animal fats may work best for you. (Still concerned about the recent claims that coconut oil is bad for you? Our article on coconut oil will help clear up the confusion.)

Bulk buy and cook. If you’re someone who doesn’t like to spend a lot of time in the kitchen, this is the best of both worlds. Buying your food at bulk (specifically from wholesalers) can reduce the cost per pound tremendously. Plus, you can make ahead food (bulk cook chicken thighs for pre-made meat, or cook entire meals) that are used as leftovers, so you spend less time cooking.


Leftovers will be another thing we will take into consideration. Not only is it easier on you, but why put yourself through the hassle to cook the same food more than once? Breakfast is something I normally do leftover style, where I don’t have to worry about it in the morning and I certainly don’t have to stress about it. Grab some food out the fridge, pre-made for me, and head out the door. It doesn’t get much easier than that, does it? 
×