Because people with type 2 diabetes are at an increased risk for cardiovascular disease, there’s a specific concern that the saturated fat in the diet may drive up LDL, or “bad,” cholesterol levels, and further increase the odds of heart problems. If you have type 2 diabetes, talk to your doctor before attempting a ketogenic diet. They may recommend a different weight-loss diet for you, like a reduced-calorie diet, to manage diabetes. Those with epilepsy should also consult their doctor before using this as part of their treatment plan.
Since my numbers were high my doc ordered a calcium scoring test which shows some mild calcium increase in my lower depending artery which is not normal for a female of my age and health. Initially he wanted me to abandon the diet and follow a Mediterranean low fat diet. I suggested I eat more monounsaturated fats but stay on the low carb diet and he agreed. I have seen a great deal of benefit from the low carb diet and am unwilling to give it up at this time.
Fat is the primary source of fuel on a ketogenic diet, and supplementing with specific types of fat, particularly coconut oil and medium-chain triglyceride (MCT) oil, can help you get into ketosis faster. MCT oil is unique in that it increases ketone levels in a linear, dose-dependent manner and allows for the induction of ketosis with lower amounts of total fat in the diet. (44)
High levels of triglycerides in the blood are thought to be a sign of poor metabolism. Poor metabolism, or metabolic disorders, are associated with obesity, diabetes, heart disease and cancer. Often times, elevated triglycerides are a byproduct of insulin resistance. In these cases, a ketogenic diet is an excellent strategy to improve those numbers.
There are now a number of different diets that can be used for epilepsy: the Classic Ketogenic Diet, the Modified Atkins Diet, the Medium Chain Triglyceride Diet and the Low Glycemic Index Treatment Diet. The choice is made after the initial consultation, and depends on the epilepsy diagnosis, the child’s age and feeding habits, and family needs and preferences.
“Because cancer cells prefer to use glucose, diets that limit glucose may be beneficial,” Barbara Gower, PhD, senior author and professor in the Department of Nutrition Sciences, said in a statement. “Because they limit glucose and several growth factors, ketogenic diets will limit the ability of cancer to grow, which gives the patient’s immune system time to respond.”
Cancer cells need to carefully maintain their “redox status”. Redox status is the balance between oxidants and antioxidants. Oxidants, including free radicals and other “reactive” chemical species, are made continuously in every living cell as a byproduct of metabolic activities. Several antioxidant systems have evolved in our body to specifically counter the harmful actions of these oxidants.
Available research on the ketogenic diet for weight loss is still limited. Most of the studies so far have had a small number of participants, were short-term (12 weeks or less), and did not include control groups. A ketogenic diet has been shown to provide short-term benefits in some people including weight loss and improvements in total cholesterol, blood sugar, and blood pressure. However, these effects after one year when compared with the effects of conventional weight loss diets are not significantly different. 
Researchers also observed that the size of VLDL particle size did not change in either of the groups. However, they noted that the total number of VLDL particles decreased by 19% from 76.2 nmol/L to 61.7 nmol/L.  More specifically, large VLDL particles reduced by 40.2% from 3.33 nmol/L to 1.74 nmol/L, medium VLDL particles decreased by 4.8% from 46.2 nmol/L to 44 nmol/L. 
I also might offer a thought as to why, from a more esoteric, more biochemical perspective, for most people diagnosed with cancer the ketogenic diet might not work. For the past 150 years, researchers have approached cancer as a disease in which perfectly happy, normal mature cells sitting in some tissue somewhere suddenly go awry, lose their normal regulatory restraint, develop a primitive, undifferentiated appearance or phenotype, begin proliferating without restraint, begin invading through tissues and organs, begin migrating, spreading, creating new blood vessels along the way to feed the rapacious appetite of cancer. But over the past 15 years, gradually, a new, more productive, and I believe more truthful hypothesis has emerged, spearheaded particularly by Dr. Max Wicha at the University of Michigan. Scientists such as Dr. Wicha have discovered that cancer may be a little more complicated than we have thought these long decades.
One downside to a ketogenic diet for weight loss is the difficulty maintaining it. “Studies show that weight loss results from being on a low-carb diet for more than 12 months tend to be the same as being on a normal, healthy diet,” says Mattinson. While you may be eating more satiating fats (like peanut butter, regular butter, or avocado), you’re also way more limited in what’s allowed on the diet, which can make everyday situations, like eating dinner with family or going out with friends, far more difficult. Because people often find it tough to sustain, it’s easy to rely on it as a short-term diet rather than a long-term lifestyle.
A popular keto supplement are exogenous ketones (popularly called “keto diet pills”) that may help you achieve results earlier as well as remain in that state. (Don’t confuse exogenous ketones with raspberry ketones, as the latter don’t raise ketone levels in the body or mimic endogenous ketones, so you wouldn’t use raspberry ketones in your regimen.)
Hi. Glad to see my bad cholesterol is not the only one that’s gone up. The day before I started Keto my bad cholesterol was 93 and my “good” was 107. A month later, I got my blood taken again and my bad had increased to 137 but my good thankfully had only decreased by 2, to 105. The Dr. said that the good news about that was that the “good” cholesterol was the one that protected the heart so nothing needed to be done, as yet. I also have no intention of taking cholesterol meds. Want to go to my grave with as few meds as possible. However, yes, my plan has been to increase eating more “healthy” fats, like Extra Virgin Olive Oil, avacadoes (one a day is prime) and nuts like manademias (which are considered the “wonder nut”). I still eat bacon, butter and eggs but am hoping the increase in healthy fats will show good results in the cholesterol levels. We’ll see.
Cyclical ketosis means you’re sometimes in ketosis and sometimes aren’t. A few days each week—the night before workout days to build glycogen stores in your muscles—try increasing your intake of berries, higher complex carb veggies (like sweet potatoes), and non-gluten grains. It might knock you out of ketosis temporarily, but it also provides a wealth of nutrients to keep you lean, healthy, and happy. This is also called flexible ketosis, which creates metabolic flexibility—the holy grail of metabolism management. I’ve also talked about cycling ketosis with intermittent fasting, which provides a win-win strategy to reach your health goals.
The Keto diet emphasizes weight loss through fat-burning. The goal is to quickly lose weight and ultimately feel fuller with fewer cravings, while boosting your mood, mental focus and energy. According to Keto proponents, by slashing the carbs you consume and instead filling up on fats, you safely enter a state of ketosis. That’s when the body breaks down both dietary and stored body fat into substances called ketones. Your fat-burning system now relies mainly on fat – instead of sugar – for energy. While similar in some ways to familiar low-carb diets, the Keto diet’s extreme carb restrictions – about 20 net carbs a day or less, depending on the version – and the deliberate shift into ketosis are what set this increasingly popular diet apart.
But what surprised me – and what began to concern others I knew in the medical community – was some time later the deafening silence about the trial’s outcome, and what seemed to be a blackout about the actual data. Eventually, the study results were published indicating that 42 subjects had been ultimately recruited for the trial, not the planned 70, and not a single one of these had responded to the drug.
“However, we did not find a clear correlation between how much they preferred fat and how well they later did with either the KD or MAD. There was a slight hint that those with seizure freedom with the KD or MAD were those with the highest fat preference, but it wasn’t statistically significant overall,” said Kossoff. “Although interesting, the idea of fat preference being a screening test for going on the KD or MAD doesn’t appear to be valid. However, tt also tells us that if a child does not prefer fat, it does not mean they shouldn’t go on the KD or MAD.”
Only after interviewing 1,000 of Dr. Kelley’s patients, and evaluating 455 of them at length over a five-year period, did I even begin to think about the book that would be written – not a popular potboiler, not a tome expounding his elaborate theories, but a serious academic monograph about our findings. It is just not in my makeup to put out a book with lovely theory and two case reports, however inspiring they might be.
Another mouse study cited by Seyfried is one in which dietary restriction was reported to promote vessel maturation in a mouse astrocytoma model. Given that tumor angiogenesis is one of my scientific interests and I have a fair number of publications on the topic, I was interested. Unfortunately, I ended up being disappointed. This was another syngeneic model (i.e., a mouse tumor implanted in mice of the same strain from which the tumor was isolated as a cell line, like the one discussed above). Although it showed increased tumor vessel maturation (which is one mechanism by which inhibitors of angiogenesis work), I wasn’t quite convinced, because there was a distinct lack of quantification of the phenomenon, and the microscopy appears not to have been blinded, something that’s critical to avoid unconscious bias in the results. It’s not surprising that this result, which, if more convincing evidence had been obtained, could easily have appeared in Cancer Research, was published in a low tier journal. It’s an OK study, but not fantastic. Certainly it didn’t lead me to smacking myself in forehead and saying, “Of course!”
When in the hospital, glucose levels are checked several times daily and the patient is monitored for signs of symptomatic ketosis (which can be treated with a small quantity of orange juice). Lack of energy and lethargy are common, but disappear within two weeks. The parents attend classes over the first three full days, which cover nutrition, managing the diet, preparing meals, avoiding sugar, and handling illness. The level of parental education and commitment required is higher than with medication.
Pattern B LDL, on the other hand, has a much smaller particle size and is much more prone to oxidation. Another thing about pattern B LDL is that it is small enough to enter into the endothelial lining of the artery where it can become oxidized and more likely to form plaque. There is a high association between these small dense particles and cardiovascular disease.
The ketogenic diet may have a role in treating disorders of cellular proliferation, especially cancer. Just as chemotherapy selectively targets tumors based on differences in the way they divide compared with normal cells, investigators have proposed targeting tumors on the basis of differences in their metabolism. Normal tissue can adapt readily to using ketones (instead of glucose) as a substrate, but malignant cells probably do not have the same degree of metabolic flexibility . One case report in 1995 [24, Class III] described the use of the ketogenic diet in two girls with advanced astrocytomas, based on the idea that brain tumors are less able than healthy brain tissue to use ketones as an energy source. In this report, PET studies demonstrated a 20% reduction in glucose uptake by the tumors following the initiation of the ketogenic diet. One of the patients actually showed improvement during the course of the study and has continued to be well, without evidence of tumor progression (T. Seyfried, personal communication, 2008).
Leanne: Totally, awesome, perfect. Today we’ve really come together to talk about cholesterol. It is a huge topic. Yeah, Cholesterol Clarity right there. A lot of my readers who are adopting this high fat, keto eating style are getting really nervous about cholesterol and you know if I eat too many eggs is my cholesterol going to go up and so a lot of people that are watching this show today, I bet you about 80% of them have their blood work in front of them.
Everyone talks about upping their fats… I do not think that is the key to sweeping LDL out of the system. Upping cruciferous fiberous veggies… the fiber, vitamins and minerals contained in veggies bind with the LDL and move it on out. You would have to eat literally a truck load to make any serious dent in your daily carb allowance since most are very low net carb anyways.
Jimmy Moore: Yeah, just be in control of your own health. That’s the major theme that I’ve tried to push the last couple years. I’m tired of people advocating their responsibility for their own health to a dietitian, to a doctor, there’s just way too many resources. This YouTube channel you’re watching right now is just unbelievable for content, my podcasts, books, there’s all sorts of information that’s out there. A lot of it for free, take advantage of that because I think the more you know the more empowered you can be and whether doctors and dietitians and all these medical professionals like it or not, the empowered patient is the future of healthcare. I think if we’re going to really make a difference in our own lives, and then collectively as a culture in our health, it has to start with the individual caring again.
Implementing the diet can present difficulties for caregivers and the patient due to the time commitment involved in measuring and planning meals. Since any unplanned eating can potentially break the nutritional balance required, some people find the discipline needed to maintain the diet challenging and unpleasant. Some people terminate the diet or switch to a less demanding diet, like the modified Atkins diet or the low-glycaemic index treatment diet, because they find the difficulties too great.
A ketogenic diet typically leads to a broad range of improvements in blood lipids as well as other cardiovascular risk factors such as blood pressure and inflammation. However, the changes we see in total and LDL cholesterol levels are much less predictable than the changes in other blood lipids such as triglycerides and HDL cholesterol. For some people, calculated LDL cholesterol goes down, and for others it goes up, sometimes quite a bit. This tendency for some people to see an increase in their LDL cholesterol has been a focus of research over the last decade because the question remains – “What, if anything, does this tell us when assessing one’s risk of heart disease?”
We decided to join a ketogenic diet study. Not something you would have expected for cancer treatment. This wasn’t a random decision because there are many studies looking at how diets might improve cancer outcomes. I joined Alina as a coach and chef. You probably have heard about the “ketogenic” diet. It consists of lots of fat, some protein, and minimal carbs. Using this diet, our body switches from glucose as a fuel source to ketones. Carbs are strictly for those must-have nutrients.
The ketogenic diet (also known as the "keto diet") is a high fat, low carbohydrate, and "just enough" protein for growth and maintenance diet. Typically, it follows a ratio of 3-4 grams of fat for every 1 gram of carbohydrate and protein. This means that about 90% of the calories come from fat, requiring those on the diet to eat mostly fatty foods such as butter and cream. Although it may sound terrible, there are many creative recipes that make this a tasty approach. What distinguishes the traditional ketogenic diet from the modified-Atkins diet is the rigorous attention to food intake and limitation on total calories.
The KDE is usually begun in a hospital setting, and often begins with a one- to two-day fasting period (though there may be a trend away from both of these requirements). After determining the proper amount of protein (depending on age, etc.), the diet is structured as a ratio of fat grams to protein grams plus carb grams. It usually begins with a 4 to 1 ratio, and then can be fine-tuned from there. The diet is often calorie-limited and fluid-limited as well. Additionally, no packaged "low-carb foods" (shakes, bars, etc.) are allowed for at least the first month.
Bonnie J. Brehm, Randy J. Seeley, Stephen R. Daniels, and David A. D’Alessio, “A Randomized Trial Comparing a Very Low Carbohydrate Diet and a Calorie-Restricted Low Fat Diet on Body Weight and Cardiovascular Risk Factors in Healthy Women,” The Journal of Clinical Endocrinology & Metabolism: Vol 88, No 4; January 14, 2009. http://press.endocrine.org/doi/full/10.1210/jc.2002-021480.
Make things yourself. While it’s extremely convenient to buy most things pre-made or pre-cooked, it always adds to the price per pound on items. Try prepping veggies ahead of time instead of buying pre-cut ones. Try making your stew meat from a chuck roast. Or, simply try to make your mayo and salad dressings at home. The simplest of things can work to cut down on your overall grocery shopping.
So sugar feeds the cancer cells- you dont have to go full keto just stop eating sugar? I keep reading meat causes cancer and a vegan diet is best! When you cut out sugar and all grains you end up eating dairy and meat, with nuts for a treat. Friut is off the list, honey and some root veg like potatos so if you cut down on meat what the feck are we left with? you can only eat so many eggs,avocados and spinach. I also am yet to find a keto dessert I like, coconut flour and stevia dosent make a cake.
Kidney stones have occurred in about 6 percent of patients and may be increased in younger patients (<3 years of age), and those with hypercalciuria and low urine volume. Oral potassium citrate as a preventative supplement results in urine alkalinization, decreasing the prevalence of kidney stones. Universal supplementation appears to drop the risk of stones to nearly zero.
Typically known as the “bad cholesterol” to its healthy counterpart HDL cholesterol, increased levels of LDL cholesterol are associated with an increased risk of cardiovascular diseases (CVD).  Some studies show a strong correlation between LDL cholesterol and the risk of cardiovascular diseases in both men and women.  Evidence also suggests that decreasing blood levels of LDL-C reduces the risk of CVD. 
Dr. Gonzalez wrote an eight part article series for Natural Health 365 on the history and failure of the ketogenic diet for cancer. Dr. Gonzalez’s nutritional cancer treatment expertise is much deeper than ANYONE currently promoting the ketogenic diet for cancer, because unlike anyone else promoting it, he actually treats cancer patients with nutrition every day.
It’s not clear just how a ketogenic diet works for seizures. But Yellen says seizures are like “electrical storms” in the brain. “There are potassium channels in the brain that, when open, seem to have a quieting influence on this electrical excitation,” he says. “We think these channels work better when the brain is using ketones instead of glucose for energy.” Even when epilepsy medications have failed, a ketogenic diet can work wonders, he says.
Essentially, the keto diet for beginners works by “tricking” the body into acting as if its fasting (while reaping intermittent fasting benefits), through a strict elimination of glucose that is found in carbohydrate foods. Today the standard keto diet goes by several different names, including the “low-carbohydrate” or “very-low-carbohydrate ketogenic diet”(LCKD or VLCKD for short).
When ketone bodies accumulate in the blood, this is called ketosis. Healthy individuals naturally experience mild ketosis during periods of fasting (e.g., sleeping overnight) and very strenuous exercise. Proponents of the ketogenic diet state that if the diet is carefully followed, blood levels of ketones should not reach a harmful level (known as “ketoacidosis”) as the brain will use ketones for fuel, and healthy individuals will typically produce enough insulin to prevent excessive ketones from forming.  How soon ketosis happens and the number of ketone bodies that accumulate in the blood is variable from person to person and depends on factors such as body fat percentage and resting metabolic rate. 
One way to find out if the keto diet is helping quell your chronic inflammation is by seeing how your C-reactive protein (CRP) levels change over time on your routine blood test.  If CRP levels decrease after you’ve made your lifestyle and dietary changes, then you are on the right track. The ideal result is if your cholesterol levels are optimized along with that.
If your child is helped by the diet and seizures are better controlled, your child may remain on the ketogenic diet for 2 to 3 years, or longer. The length of time on the diet will be determined by several factors, including how well the diet helps your child, whether your child can be weaned off seizure medications, and your willingness to continue the diet.
Researchers believe that the ketogenic diet can also help patients with schizophrenia to normalize the pathophysiological processes that are causing symptoms like delusions, hallucinations, lack of restraint and unpredictable behavior. One study found that the keto diet lead to elevated concentrations of kynurenic acid (KYNA) in the hippocampus and striatum, which promotes neuroactive activity. Some studies even point to the elimination of gluten as a possible reason for improved symptoms, as researchers observed that patients with schizophrenia tended to eat more carbohydrates immediately before a psychotic episode. (19)
One study assessed the effect of dietary interventions on quality of life, cognition and behavioural functioning, reporting participants in the KD group to be more active, more productive and less anxious after four months, compared to the control group. However, no significant difference was found in quality‐adjusted life years (QALYs) between the KD group and control group at four or 16 months (GRADE rating very low).
There are several studies indicating that ketogenic diets are safe for a variety of conditions on a short-term basis. A very strict form of the ketogenic diet has been used in epileptic patients longer term (several years) and is considered safe for that purpose. The keto diet recommended on this blog for weight loss and overall health is much less restrictive, including being higher in protein and carbs than a standard ketogenic diet for epilepsy. As the diet grows in popularity, at some point we will have long-term data on people that follow a keto lifestyle for diabetes, weight loss, and other conditions.
You can change that genetics. I can’t change the genetic tendency, it’s going to be there. By golly, I’m going to pay attention to everything that I put in my mouth for that sake alone. Anyone with that kind of history, I don’t think it’s reason to freak out. I don’t think it’s a reason to think it’s an inevitability for you. It’s just one of those things that you have to pay attention to all of your numbers, anal retentively. That’s why I pay attention to my HSCRP so closely, that’s why I run my numbers so often. I know I have that tendency. I probably, had I not lost the 180 pounds in 2004, I would be in an early grave just like my brother.